Cross-talk between adipose tissue and central nervous system (CNS) underlies the
increased risk of obese people to develop brain diseases such as cognitive and mood …

Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of
energy homeostasis and body weight. Leptin deficiency or genetic defects in the …

Background Mounting evidence suggests that the choroid plexus (CP) plays an important
role in the pathophysiology of Alzheimer disease (AD), but its imaging profile in cognitive …

Leptin is the most critical hormone in the homeostatic regulation of energy balance among
those so far discovered. Leptin primarily acts on the neurons of the mediobasal part of …

This review integrates eight aspects of cerebrospinal fluid (CSF) circulatory dynamics:
formation rate, pressure, flow, volume, turnover rate, composition, recycling and …

Obesity, which has developed into a global epidemic, is a risk factor in most chronic
diseases and some forms of malignancy. The discovery of leptin in 1994 has opened a new …

We have learned over the last several decades that the brain is an important target for
insulin action. Insulin in the central nervous system (CNS) affects feeding behavior and body …

Obesity-related leptin resistance manifests in loss of leptin's ability to reduce appetite and
increase energy expenditure. Obesity is also associated with increased activity of the …

Efficient processing of information by the central nervous system (CNS) represents an
important evolutionary advantage. Thus, homeostatic mechanisms have developed that …

Under normal physiological conditions, leptin and the leptin receptor (ObR) regulate the
body weight by balancing food intake and energy expenditure. However, this adipocyte …