UK Biobank: a globally important resource for cancer research
MC Conroy, B Lacey, J Bešević, W Omiyale… - British Journal of …, 2023 - nature.com
UK Biobank is a large-scale prospective study with deep phenotyping and genomic data. Its
open-access policy allows researchers worldwide, from academia or industry, to perform …
open-access policy allows researchers worldwide, from academia or industry, to perform …
Telomere length and chronological age across the human lifespan: A systematic review and meta-analysis of 414 study samples including 743,019 individuals
Telomere attrition is a proposed hallmark of aging. To evaluate the association of telomere
length (TL) with chronological age across the human lifespan, we conducted a systematic …
length (TL) with chronological age across the human lifespan, we conducted a systematic …
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality
Biological aging of human organ systems reflects the interplay of age, chronic disease,
lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes …
lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes …
Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis
SN Stacey, F Zink, GH Halldorsson, L Stefansdottir… - Nature Genetics, 2023 - nature.com
Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …
Alcohol consumption and telomere length: Mendelian randomization clarifies alcohol's effects
Alcohol's impact on telomere length, a proposed marker of biological aging, is unclear. We
performed the largest observational study to date (in n= 245,354 UK Biobank participants) …
performed the largest observational study to date (in n= 245,354 UK Biobank participants) …
Modifiable traits, healthy behaviours, and leukocyte telomere length: a population-based study in UK Biobank
Background Telomere length is associated with risk of several age-related diseases and
cancers. We aimed to investigate the extent to which telomere length might be modifiable …
cancers. We aimed to investigate the extent to which telomere length might be modifiable …
Leukocyte telomere length in children born following blastocyst-stage embryo transfer
C Wang, Y Gu, J Zhou, J Zang, X Ling, H Li, L Hu… - Nature medicine, 2022 - nature.com
Perinatal and childhood adverse outcomes associated with assisted reproductive
technology (ART) has been reported, but it remains unknown whether the initial leukocyte …
technology (ART) has been reported, but it remains unknown whether the initial leukocyte …
The shelterin protein expansion of telomere dynamics: Linking early life adversity, life history, and the hallmarks of aging
Aging is characterized by functional decline occurring alongside changes to several
hallmarks of aging. One of the hallmarks includes attrition of repeated DNA sequences …
hallmarks of aging. One of the hallmarks includes attrition of repeated DNA sequences …
Telomere length and brain imaging phenotypes in UK Biobank
Telomeres form protective caps at the ends of chromosomes, and their attrition is a marker of
biological aging. Short telomeres are associated with an increased risk of neurological and …
biological aging. Short telomeres are associated with an increased risk of neurological and …
The associations of socioeconomic status with incident dementia and Alzheimer's disease are modified by leucocyte telomere length: A population-based cohort study
KY Lai, C Webster, S Kumari, JEJ Gallacher… - Scientific reports, 2023 - nature.com
Socio-economic status (SES) and biological aging are risk factors for dementia, including
Alzheimer's disease, however, it is less clear if the associations with SES vary sufficiently …
Alzheimer's disease, however, it is less clear if the associations with SES vary sufficiently …