Organometallic anticancer compounds
The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …
Organometallic and coordination rhenium compounds and their potential in cancer therapy
EB Bauer, AA Haase, RM Reich, DC Crans… - Coordination Chemistry …, 2019 - Elsevier
This review focuses on cytotoxic rhenium compounds in terms of IC 50 values, their mode of
action in biological systems and their status in clinical trials. Biological studies of different …
action in biological systems and their status in clinical trials. Biological studies of different …
Underestimated potential of organometallic rhenium complexes as anticancer agents
A Leonidova, G Gasser - ACS chemical biology, 2014 - ACS Publications
In the recent years, organometallic compounds have become recognized as promising anti-
cancer drug candidates. While radioactive 186/188Re compounds are already used in …
cancer drug candidates. While radioactive 186/188Re compounds are already used in …
[HTML][HTML] Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes
YK Yan, M Melchart, A Habtemariam… - Chemical …, 2005 - pubs.rsc.org
Our work has shown that certain ruthenium (II) arene complexes exhibit promising
anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their …
anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their …
Photophysics and photochemistry of organometallic rhenium diimine complexes
This review describes the photophysics and photochemistry of various diimine rhenium (I)
tricarbonyl complexes. The exceptionally diverse photophysical behavior of these …
tricarbonyl complexes. The exceptionally diverse photophysical behavior of these …
Towards cancer cell-specific phototoxic organometallic rhenium (I) complexes
A Leonidova, V Pierroz, R Rubbiani, J Heier… - Dalton …, 2014 - pubs.rsc.org
Over the recent years, several Re (I) organometallic compounds have been shown to be
toxic to various cancer cell lines. However, these compounds lacked sufficient selectivity …
toxic to various cancer cell lines. However, these compounds lacked sufficient selectivity …
Photochemistry and photophysics of coordination compounds: rhenium
RA Kirgan, BP Sullivan, DP Rillema - Photochemistry and Photophysics of …, 2007 - Springer
This review describes recent advances in the photochemistry of complexes of the element
rhenium. It covers not only fundamental chemistry but the recent applications of these …
rhenium. It covers not only fundamental chemistry but the recent applications of these …
Identification of novel potent and non-toxic anticancer, anti-angiogenic and antimetastatic rhenium complexes against colorectal carcinoma
Combination therapy targeting both tumor growth and vascularization is considered to be a
cornerstone for colorectal carcinomas (CRC) treatment. However, the major obstacles of …
cornerstone for colorectal carcinomas (CRC) treatment. However, the major obstacles of …
Rhenium (I) polypyridine biotin isothiocyanate complexes as the first luminescent biotinylation reagents: synthesis, photophysical properties, biological labeling …
KKW Lo, MW Louie, KS Sze, JSY Lau - Inorganic chemistry, 2008 - ACS Publications
We report here the design of the first class of luminescent biotinylation reagents derived from
rhenium (I) polypyridine complexes. These complexes [Re (N− N)(CO) 3 (py-biotin …
rhenium (I) polypyridine complexes. These complexes [Re (N− N)(CO) 3 (py-biotin …
Luminescent cyclometalated iridium (III) polypyridine indole complexes synthesis, photophysics, electrochemistry, protein-binding properties, cytotoxicity, and …
JSY Lau, PK Lee, KHK Tsang, CHC Ng… - Inorganic …, 2009 - ACS Publications
A series of luminescent cyclometalated iridium (III) polypyridine indole complexes,[Ir (N∧ C)
2 (N∧ N)](PF6)(HN∧ C= 2-phenylpyridine (Hppy), N∧ N= 4-((2-(indol-3-yl) ethyl) …
2 (N∧ N)](PF6)(HN∧ C= 2-phenylpyridine (Hppy), N∧ N= 4-((2-(indol-3-yl) ethyl) …