Radical C–H functionalization represents a useful means of streamlining synthetic routes by
avoiding substrate preactivation and allowing access to target molecules in fewer steps. The …

Primary amines serve as key synthetic precursors to most other N-containing compounds,
which are important in organic and medicinal chemistry. Herein, we present a NiH-catalyzed …

Herein, we report a regiodivergent 1, n-dicarbofunctionalization of unactivated olefins
enabled by a Ni-catalyzed radical relay that forges both C (sp 3)-C (sp 3) and C (sp 2)–C (sp …

Selective functionalization of ubiquitous C–H bonds based on 1, n-metal migration provides
an attractive and sustainable route to access complex molecules from readily available …

Cyclic sulfones have demonstrated important applications in drug discovery. However, the
catalytic and enantioselective synthesis of chiral cyclic sulfones remains challenging …

Complementary to the design of a single structurally complex chiral ligand to promote each
step in transition‐metal catalysis, multiligand relay catalysis through dynamic ligand …

The conventional approach to developing asymmetric synthetic methods relies heavily on
empirical optimization. However, the integration of artificial intelligence (AI) and high …

Divergent catalysis represents an exciting frontier for unlocking molecular structural diversity
and exploring new activation modes. Here, we report the unexpected discovery of polarity …

The development of a catalytic method for stereogenic carbon center formation holds
immense significance in organic synthesis. Transition-metal-catalyzed cross-coupling …

The catalytic hydrofunctionalization of alkenes with nucleophiles via the generation of
carbocationic intermediates has been extensively studied as an efficient strategy for the …