Translational opportunities in animal and human models to study alcohol use disorder

SJ Nieto, EN Grodin, CG Aguirre, A Izquierdo… - Translational …, 2021 - nature.com
Animal and human laboratory paradigms offer invaluable approaches to study the complex
etiologies and mechanisms of alcohol use disorder (AUD). We contend that human …

Resurgence of ethanol seeking following voluntary abstinence produced by nondrug differential reinforcement of other behavior

AR Craig, CN Agnew, KE Derrenbacker… - Journal of the …, 2024 - Wiley Online Library
Resurgence refers to the relapse of a target behavior following the worsening of a source of
alternative reinforcement that was made available during response elimination. Most …

[HTML][HTML] Understanding sex differences and the translational value of models of persistent substance use despite negative consequences

XJ Maddern, LC Walker, RG Anversa… - … of Learning and …, 2024 - Elsevier
Persistent substance use despite negative consequences is a key facet of substance use
disorder. The last decade has seen the preclinical field adopt the use of punishment to …

The influence of chromosome 4 on high ethanol consumption and blood pressure

PAR Anjos, RCN Marchette, R Kremer, N Granzotto… - Alcohol, 2022 - Elsevier
Abstract The Spontaneously Hypertensive Rats (SHR) strain was developed through
selective breeding for high systolic blood pressure. In our laboratory, we established a …

Sex-dependent effects of chronic stress on punished cocaine self-administration and cue-induced relapse to cocaine seeking

H Edson, KT Ball - Physiology & Behavior, 2022 - Elsevier
We tested the effects of chronic stress on cocaine relapse after drug-reinforced responding
was suppressed by punishment, an animal model of human relapse after self-imposed …

Abstinence as Choice: Exploring Voluntary Abstinence from Alcohol Self-Administration Using the Resurgence-as-Choice Framework

AR Craig, SW Smith, RW Nall, WE Sullivan… - … on Behavior Science, 2024 - Springer
Resurgence is an increase in the rate of a previously suppressed behavior that occurs when
an alternative source of reinforcement is made worse in some way. The Resurgence as …

Resurgence and Behavioral Contrast, Compared and Contrasted

KA Lattal, AK Miles - Perspectives on Behavior Science, 2024 - Springer
This is a review of the relation between operant response resurgence and behavioral
contrast. Both are defined by rate changes in a target response as a function of …

Evaluating voluntary abstinence from ethanol self-administration in rats using a concurrent-chains procedure

CN Agnew, WE Sullivan, KE Derrenbacker… - Learning and …, 2024 - Elsevier
This pilot study aimed to examine voluntary abstinence from, and relapse of, ethanol
seeking following removal of alternative nondrug reinforcement using a concurrent-chains …

Drug versus non‐drug behaviors: A dual‐reward model of sex differences and neurobiological mechanisms in rats

RW Nall, RM Chalhoub… - Journal of the …, 2022 - Wiley Online Library
Substance Use Disorders (SUDs) are an impactful problem characterized by chronic relapse
and engagement in drug‐related behaviors at the expense of non‐drug behaviors. Brain …

A Comparison of the Relative Magnitude of Combinations of Relapse Types in Rats

M Bridges - 2024 - digitalcommons.jsu.edu
Applied behavior analysis uses scientifically derived methods to create treatments for
socially significant behaviors. A threat to these successful treatments is the recurrence of …