The channels from the superfamily of transient receptor potential (TRP) activated by reactive
oxygen species (ROS) can be defined as redox channels. Those with the best exposure of …

Ion channels are ubiquitously expressed in almost all living cells, and are the third-largest
category of drug targets, following enzymes and receptors. The transient receptor potential …

Ferroptosis is critically involved in the pathophysiology of diabetic nephropathy (DN). As a
bioactive peptide, salusin‑β is abundantly expressed in the kidneys. However, it is unclear …

Melittin (MLT) treatment is believed to enhance tumor cell death, apoptotic, and oxidative
cytotoxic effects of cisplatin (CSP) via the modulation of Ca 2+ channels in several cancer …

Mycotoxins are secondary metabolites produced by various kinds of fungi that can induce
disease in humans. The fungal species Penicillium expansum produces patulin (C 7 H 6 O …

Host defenses in the brain are modulated by the activation of several factors such as oxygen
free radical species (ROS), Ca 2+ influx, and TRPM2 activation, and they are well-known …

Alzheimer's disease (AD) is characterized by the increase of hippocampal Ca2+ influx-
induced apoptosis and mitochondrial oxidative stress (OS). The OS is a stimulator of …

We investigated the effects of silver nanoparticle (AgNP) and cisplatin (CiSP) exposure via
the activation of TRPM2 cation channels in glioblastoma (DBTRG-05MG) cell line. The cells …

Abstract Cisplatin (CiSP) induced-overload Ca 2+ entry results in the increase of
mitochondrial oxidative stress and apoptosis in the cancer cell. TRPM2 cation channel is …

Homocysteine is an intermediate product of biochemical reactions occurring in living
organisms. It is known that drugs that increase dopamine synthesis used in Parkinson's …