Oxindole has been shown to be a pharmacologically advantageous scaffold having many
biological properties that are relevant to medicinal chemistry. The simplicity and widespread …

Cancer, which is the uncontrolled growth of cells, is the second leading cause of death after
heart disease. Targeting drugs, especially to specific genes and proteins involved in growth …

The indole moiety is one of the most widespread heterocycles found in both natural products
and biological systems. Indoles have important biological activities including anticancer …

In continuation of our previous effort, different in silico selection methods were applied to
310 naturally isolated metabolites that exhibited antiviral potentialities before. The applied …

Small-molecule kinase inhibitors are being continuously explored as new anticancer
therapeutics. Kinases are the phosphorylating enzymes which regulate numerous cellular …

In the current medical era, human health is experiencing numerous challenges, particularly
the human malignancies. Therefore, the therapeutic arsenal for these malignancies is to be …

The serine/threonine protein kinases CDK2 and GSK-3β are key oncotargets in breast
cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids …

Proceeding our prior studies of SARS-CoV-2, the inhibitory potential against SARS-CoV-2
RNA-dependent RNA polymerase (RdRp) has been investigated for a collection of 3009 …

The escalating prevalence of cancer on a global scale, coupled with the inadequacies of
present-day therapies and the emergence of drug-resistant cancer strains, has necessitated …

The discovery of cyclin-dependent kinases (CDK) and their mechanism in regulating the cell
cycle process was considered a game-changer in cancer therapy. Cell cycle arrest and …