How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia
AS Mirchandani, MA Sanchez-Garcia… - Nature Reviews …, 2024 - nature.com
Most eukaryotes require oxygen for their survival and, with increasing multicellular
complexity, oxygen availability and delivery rates vary across the tissues of complex …
complexity, oxygen availability and delivery rates vary across the tissues of complex …
[HTML][HTML] Clonal hematopoiesis and hematological malignancy
WG Dunn, MA McLoughlin, GS Vassiliou - The Journal of Clinical …, 2024 - jci.org
Clonal hematopoiesis (CH), the expansion of hematopoietic stem cells and their progeny
driven by somatic mutations in leukemia-associated genes, is a common phenomenon that …
driven by somatic mutations in leukemia-associated genes, is a common phenomenon that …
[HTML][HTML] 2-hydroxyglutarate rides the cancer-immunity cycle
Highlights•Cancer cell-derived D-and L-2HG regulate antitumor immunity.•Both 2HG
enantiomers physiologically accumulate in immune cells.•D-2HG and L-2HG should not be …
enantiomers physiologically accumulate in immune cells.•D-2HG and L-2HG should not be …
Metabolic dialogues: regulators of chimeric antigen receptor T cell function in the tumor microenvironment
J Moraly, T Kondo, M Benzaoui, J DuSold… - Molecular …, 2024 - Wiley Online Library
Tumor‐infiltrating lymphocytes (TILs) and chimeric antigen receptor (CAR) T cells have
demonstrated remarkable success in the treatment of relapsed/refractory melanoma and …
demonstrated remarkable success in the treatment of relapsed/refractory melanoma and …
Epigenetic regulation of tumor immunity
Although cancer has long been considered a genetic disease, increasing evidence shows
that epigenetic aberrations play a crucial role in affecting tumor biology and therapeutic …
that epigenetic aberrations play a crucial role in affecting tumor biology and therapeutic …
[HTML][HTML] Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity
S Feng, D Wang, Y Jin, S Huang, T Liang, W Sun, X Du… - Cell Reports, 2024 - cell.com
The high infiltration of tumor-associated macrophages (TAMs) in the immunosuppressive
tumor microenvironment prominently attenuates the efficacy of immune checkpoint blockade …
tumor microenvironment prominently attenuates the efficacy of immune checkpoint blockade …
Immunometabolism of CD8+ T cell differentiation in cancer
CD8+ cytotoxic T lymphocytes (CTLs) are central mediators of tumor immunity and
immunotherapies. Upon tumor antigen recognition, CTLs differentiate from naive/memory …
immunotherapies. Upon tumor antigen recognition, CTLs differentiate from naive/memory …