Aplastic anemia (AA) is rare disorder of bone marrow failure which if severe and not
appropriately treated is highly fatal. AA is characterized by morphologic marrow features …

Hereditary anemia has various manifestations, such as sickle cell disease (SCD), Fanconi
anemia, glucose-6-phosphate dehydrogenase deficiency (G6PDD), and thalassemia. The …

Mutations in pre-mRNA processing factors (PRPFs) cause autosomal-dominant retinitis
pigmentosa (RP), but it is unclear why mutations in ubiquitously expressed genes cause non …

The availability of in vitro models of the human retina in which to perform pharmacological
and toxicological studies is an urgent and unmet need. An essential step for developing in …

The emergence of retinal progenitor cells and differentiation to various retinal cell types
represent fundamental processes during retinal development. Herein, we provide a …

Tissue specific extracellular matrices (ECM) provide structural support and enable access to
molecular signals and metabolites, which are essential for directing stem cell renewal and …

A major goal in the stem cell field is to generate tissues that can be utilized as a universal
tool for in vitro models of development and disease, drug development, or as a resource for …

Microglia are the primary resident immune cells in the retina. They regulate neuronal
survival and synaptic pruning making them essential for normal development. Following …

The molecular mechanisms that drive hematopoietic stem cell functional decline under
conditions of telomere shortening are not completely understood. In light of recent advances …

Alternative splicing (AS) is a crucial mechanism contributing to proteomic diversity, which is
highly regulated in tissue-and development-specific patterns. Retinal tissue exhibits one of …