Mechanisms and regulation of alternative pre-mRNA splicing
Y Lee, DC Rio - Annual review of biochemistry, 2015 - annualreviews.org
Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscriptional
regulation of gene expression, providing significant expansion of the functional proteome of …
regulation of gene expression, providing significant expansion of the functional proteome of …
Context-dependent control of alternative splicing by RNA-binding proteins
XD Fu, M Ares Jr - Nature Reviews Genetics, 2014 - nature.com
Sequence-specific RNA-binding proteins (RBPs) bind to pre-mRNA to control alternative
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …
[HTML][HTML] Sequence, structure, and context preferences of human RNA binding proteins
D Dominguez, P Freese, MS Alexis, A Su, M Hochman… - Molecular cell, 2018 - cell.com
RNA binding proteins (RBPs) orchestrate the production, processing, and function of
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …
mRNAs. Here, we present the affinity landscapes of 78 human RBPs using an unbiased …
Diverse alternative back-splicing and alternative splicing landscape of circular RNAs
Circular RNAs (circRNAs) derived from back-spliced exons have been widely identified as
being co-expressed with their linear counterparts. A single gene locus can produce multiple …
being co-expressed with their linear counterparts. A single gene locus can produce multiple …
[HTML][HTML] Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction
MJ Shurtleff, MM Temoche-Diaz, KV Karfilis, S Ri… - elife, 2016 - elifesciences.org
Exosomes are small vesicles that are secreted from metazoan cells and may convey
selected membrane proteins and small RNAs to target cells for the control of cell migration …
selected membrane proteins and small RNAs to target cells for the control of cell migration …
A day in the life of the spliceosome
One of the most amazing findings in molecular biology was the discovery that eukaryotic
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …
Efficient backsplicing produces translatable circular mRNAs
Y Wang, Z Wang - Rna, 2015 - rnajournal.cshlp.org
While the human transcriptome contains a large number of circular RNAs (circRNAs), the
functions of most circRNAs remain unclear. Sequence annotation suggests that most …
functions of most circRNAs remain unclear. Sequence annotation suggests that most …
[HTML][HTML] Anti-tumor activity of the type I PRMT inhibitor, GSK3368715, synergizes with PRMT5 inhibition through MTAP loss
A Fedoriw, SR Rajapurkar, S O'Brien, SV Gerhart… - Cancer cell, 2019 - cell.com
Type I protein arginine methyltransferases (PRMTs) catalyze asymmetric dimethylation of
arginines on proteins. Type I PRMTs and their substrates have been implicated in human …
arginines on proteins. Type I PRMTs and their substrates have been implicated in human …
[HTML][HTML] SR proteins: binders, regulators, and connectors of RNA
S Jeong - Molecules and cells, 2017 - Elsevier
Serine and arginine-rich (SR) proteins are RNA-binding proteins (RBPs) known as
constitutive and alternative splicing regulators. As splicing is linked to transcriptional and …
constitutive and alternative splicing regulators. As splicing is linked to transcriptional and …
Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate
Alternative splicing modulates expression of most human genes. The kinetic model of
cotranscriptional splicing suggests that slow elongation expands and that fast elongation …
cotranscriptional splicing suggests that slow elongation expands and that fast elongation …