Epigenetics as a mediator of plasticity in cancer

AP Feinberg, A Levchenko - Science, 2023 - science.org
The concept of an epigenetic landscape describing potential cellular fates arising from
pluripotent cells, first advanced by Conrad Waddington, has evolved in light of experiments …

Drug-tolerant persister cells in cancer: the cutting edges and future directions

Y Pu, L Li, H Peng, L Liu, D Heymann… - Nature Reviews …, 2023 - nature.com
Drug-tolerant persister (DTP) cell populations were originally discovered in antibiotic-
resistant bacterial biofilms. Similar populations with comparable features have since been …

Nanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment

Y Xiong, Y Rao, J Hu, Z Luo, C Chen - Advanced materials, 2023 - Wiley Online Library
Rapid advancements in materials science and nanotechnology, intertwined with oncology,
have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy …

Dormancy, stemness, and therapy resistance: interconnected players in cancer evolution

F Francescangeli, ML De Angelis, R Rossi… - Cancer and Metastasis …, 2023 - Springer
The biological complexity of cancer represents a tremendous clinical challenge, resulting in
the frequent failure of current treatment protocols. In the rapidly evolving scenario of a …

PINK1-mediated mitophagy promotes oxidative phosphorylation and redox homeostasis to induce drug-tolerant persister cancer cells

Y Li, H Chen, X Xie, B Yang, X Wang, J Zhang, T Qiao… - Cancer Research, 2023 - AACR
The drug-tolerant persister (DTP) state enables cancer cells to evade cytotoxic stress from
anticancer therapy. However, the mechanisms governing DTP generation remain poorly …

The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity

X Sun, L He, H Liu, RF Thorne, T Zeng, L Liu, B Zhang… - Cell Metabolism, 2023 - cell.com
In response to adverse environmental conditions, embryonic development may reversibly
cease, a process termed diapause. Recent reports connect this phenomenon with the non …

Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma

Z Xiong, SL Chan, J Zhou, JSL Vong, TT Kwong… - Gut, 2023 - gut.bmj.com
Objective Therapy-induced tumour microenvironment (TME) remodelling poses a major
hurdle for cancer cure. As the majority of patients with hepatocellular carcinoma (HCC) …

Rewiring of mitochondrial metabolism in therapy-resistant cancers: permanent and plastic adaptations

KE Pendleton, K Wang, GV Echeverria - Frontiers in Cell and …, 2023 - frontiersin.org
Deregulation of tumor cell metabolism is widely recognized as a “hallmark of cancer.” Many
of the selective pressures encountered by tumor cells, such as exposure to anticancer …

Tumor-promoting aftermath post-chemotherapy: A focus on breast cancer

P Famta, S Shah, N Jain, KC Kumar, D Bagasariya… - Life sciences, 2022 - Elsevier
Chemotherapy is an important tool for the management of solid tumors including breast
cancers (BC). Its neo-adjuvant and adjuvant use is important for shrinking tumor size and …

FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters

M Li, T Nishimura, Y Takeuchi, T Hongu… - The Journal of …, 2023 - Am Soc Clin Investig
The heterogeneity of cancer stem cells (CSCs) within tumors presents a challenge in
therapeutic targeting. To decipher the cellular plasticity that fuels phenotypic heterogeneity …