The Warburg effect, characterized by the preferential conversion of glucose to lactate even
in the presence of oxygen and functional mitochondria, is a prominent metabolic hallmark of …

Mitosis mediates the accurate separation of daughter cells, and abnormalities are closely
related to cancer progression. KIF11, a member of the kinesin family, plays a vital role in the …

Eg5 is a protein encoded by KIF11 gene and is primarily involved in correct mitotic cell
division. It is also involved in nonmitotic processes such as polypeptide synthesis, protein …

Hypoxia-inducible transcription factors (HIFs) are key transcription factors for cellular
response to low oxygen levels. However, the specific mediators responsible for activating …

Objective Glioblastoma (GBM) has poor clinical prognosis due to limited treatment options.
In addition, the current treatment regimens for GBM may only slightly prolong patient …

Drug resistance of malignant tumor leads to disease progression be the bottleneck in clinical
treatment. Antiangiogenic therapy, which aims to “starve” the tumor by inhibiting …

Background: Glioblastoma (GBM) is a common and highly aggressive brain tumor with a
poor prognosis for patients. It is urgently needed to identify potential small molecule drugs …