It is well known that small molecule colloidal aggregation is a leading cause of false
positives in early drug discovery. Colloid-formers are diverse and well represented among …

Abstract “There's plenty of room at the bottom”(Richard Feynman, 1959): an invitation for
(metalla) carboranes to enter the (new) field of nanomedicine. For two decades, the number …

The current state of chemotherapy is far from satisfaction, restricted by the inefficient drug
delivery and the off‐target toxicity. Prodrug nanoassemblies are emerging as efficient …

Owing to the harsh downhole environments, poor dispersion of multi-walled carbon
nanotubes (MWCNTs) at high salinity and high temperature can severely limit their …

Here, we report the proof-of-concept for controlled aggregation in a binary colloidal system.
The binary systems are studied by varying bond flexibility of only one species, while the …

Colloidal drug aggregates have been a nuisance in drug screening, yet, because they
inherently comprise drug-rich particles, they may be useful in vivo if issues of stability can be …

Local anesthetics (LAs) are drugs that promote the reversible blocking of neural
transmission by inhibiting the excitation conduction process in peripheral nerves. Tetracaine …

Small molecules can self-assemble in aqueous solution into a wide range of nanoentity
types and sizes (dimers, n-mers, micelles, colloids, etc.), each having their own unique …

Colloidal drug aggregates enable the design of drug‐rich nanoparticles; however, the
efficacy of stabilized colloidal drug aggregates is limited by entrapment in the endo …

Hypothesis Colloidal aggregation phenomena have been found responsible for the
supersaturation of poorly water-soluble drugs, potentially leading to bioavailability …