Myocardial infarction (MI) is the irreversible death of cardiomyocyte secondary to prolonged
lack of oxygen or fresh blood supply. Historically considered as merely cardiomyocyte …

The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …

▪ Abstract Molecular chaperones, including the heat-shock proteins (Hsps), are a ubiquitous
feature of cells in which these proteins cope with stress-induced denaturation of other …

Our cells and tissues are challenged constantly by exposure to extreme conditions that
cause acute and chronic stress. Consequently, survival has necessitated the evolution of …

The human heat shock protein 70 (Hsp70) family contains at least eight homologous
chaperone proteins. Endoplasmatic reticulum and mitochondria have their specific Hsp70 …

Heat shock proteins (HSPs) are detected in all cells, prokaryotic and eukaryotic. In vivo and
in vitro studies have shown that various stressors transiently increase production of HSPs as …

For a long time necrosis was considered as an alternative to programmed cell death,
apoptosis. Indeed, necrosis has distinct morphological features and it is accompanied by …

The heat shock response, characterized by increased expression of heat shock proteins
(Hsps) is induced by exposure of cells and tissues to extreme conditions that cause acute or …

How a cell responds to stress is a central problem in cardiovascular biology. Diverse
physiological stresses (eg, heat, hemodynamics, mutant proteins, and oxidative injury) …

Heat shock proteins (Hsps) have been studied for many years and there is now a large body
of evidence that demonstrates the role of Hsp upregulation in tissue and cell protection in a …