Address reprint requests to Barrett J. Rollins, MD, PhD, Dana-kines than humans (for
example, there is no clear-cut murine Farber Cancer Institute, 44 Binney St, Boston, MA …

Interleukin 8, the first chemokine to be characterized, was discovered nearly ten years ago.
Today, more than 30 human chemokines are known. They are often upregulated in …

The gut microbiota has been causally linked to cancer, yet how intestinal microbes influence
progression of extramucosal tumors is poorly understood. Here we provide evidence …

Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β are highly related members of
the CC chemokine subfamily. Despite their structural similarities, MIP-1α and MIP-1β show …

Chemokines are small peptides that are potent activators and chemoattractants for leukocyte
subpopulations and some nonhemopoietic cells. Their actions are mediated by a family of 7 …

Airways inflammation is thought to play a central role in the pathogenesis of asthma.
However, the precise role that individual inflammatory cells and mediators play in the …

Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

Cytokines are usually extracellular signalling proteins, usually less than 80 kD in size, and
many are glycosylated. They are produced by many diVerent cell types that are involved in …

Innate immune system is the first line of defence against invading pathogens that is critical
for the overall survival of the host. Human liver is characterised by a dual blood supply, with …

Migration of leukocytes from the bone marrow to the circulation, the primary lymphoid organs
and inflammatory sites is directed by chemokines and specific receptor interactions. Besides …