Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

Bacterial infections represent a significant health threat globally, and are responsible for the
majority of hospital-acquired infections, leading to extensive mortality and burden on global …

Covering: up to the end of 2016 Novel antimicrobial drugs are continuously needed to
counteract bacterial resistance development. An innovative molecular design strategy for …

New strategies are urgently needed to target MRSA, a major global health problem and the
leading cause of mortality from antibiotic-resistant infections in many countries. Here, we …

This review is aimed to provide extensive survey of quinolones and fluoroquinolones for a
variety of applications ranging from metal complexes and nanoparticle development to …

Although internationally recognized as the “highest priority critically important
antimicrobials,” fluoroquinolones are extensively used in both human and veterinary …

Seven conjugates composed of well-known fluoroquinolone antibacterial agents,
ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 …

In this work, a series of novel moxifloxacin-amide-1, 2, 3-triazole-isatin hybrids 7a-l were
designed and synthesized. The in vitro antibacterial activity against a panel of clinically …

Many antimicrobial drugs are poorly active against pathogenic microbes causing
intracellular infections, such as Mycobacterium tuberculosis or Plasmodium falciparum. On …

The purpose of this study was to prepare various novel amide tethered ciprofloxacin-1, 2, 3-
triazole-isatin hybrids 7a-l, and evaluate their in vitro anti-mycobacterial activity as well as …