The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

Recurrent glomerular disease after kidney transplant remains an important cause of allograft
failure. Many of the different entities post-transplant still suffer from incomplete knowledge on …

Recent advances in surgical, immunosuppressive and monitoring protocols have led to the
significant improvement of overall one-year kidney allograft outcomes. Nonetheless, there …

Kidney diseases form part of the major health burdens experienced all over the world.
Kidney diseases are linked to high economic burden, deaths, and morbidity rates. The great …

Thrombotic microangiopathy (TMA) is defined by specific clinical characteristics, including
microangiopathic hemolytic anemia, thrombocytopenia, and pathologic evidence of …

Background: C3 glomerulopathy (C3G), a rare glomerular disease mediated by alternative
complement pathway dysregulation, is associated with a high rate of recurrence and graft …

Diabetic kidney disease (DKD) affects 30–40% of patients with diabetes and is currently the
leading cause of end-stage renal disease (ESRD). The activation of the complement …

Background The long-term mortality of kidney transplantation patients with atypical
hemolytic uremic syndrome remains high, and the efficacy of the main treatment eculizumab …

Hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenia purpura (TTP) are rare
diseases sharing a common pathological feature, thrombotic microangiopathy (TMA). TMA is …

Genetic testing has uncovered rare variants in complement proteins associated with
thrombotic microangiopathy (TMA) and C3 glomerulopathy (C3G). Approximately 50% are …