The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Oils in the form of triacylglycerols are the most abundant energy-dense storage compounds
in eukaryotes, and their metabolism plays a key role in cellular energy balance, lipid …

Interactions between the gut microbial ecosystem and host lipid homeostasis are highly
relevant to host physiology and metabolic diseases. We present a comprehensive multi …

The classic toxicity of carbon tetrachloride (CCl4) is to induce liver lesion and liver fibrosis.
Liver fibrosis is a consequence of chronic liver lesion, which can progress into liver cirrhosis …

The endoplasmic reticulum (ER) is an interconnected network of tubular and planar
membranes that supports the synthesis and export of proteins, carbohydrates and lipids …

Drug resistance and relapse remain key challenges in pancreatic cancer. Here, we have
used RNA sequencing (RNA-seq), chromatin immunoprecipitation (ChIP)-seq, and genome …

Mutations in human LPIN2 produce a disease known as Majeed syndrome, the clinical
manifestations of which are ameliorated by strategies that block IL-1β or its receptor …

The regulation of glycerolipid biosynthesis is critical for homeostasis of cellular lipid stores
and membranes. Here we review the role of lipin phosphatidic acid phosphatase enzymes …

Triacylglycerols (TAG) serve as the predominant form of energy storage in mammalian cells,
and TAG synthesis influences conditions such as obesity, fatty liver, and insulin resistance …

Cells require a constant supply of fatty acids to survive and proliferate. Fatty acids
incorporate into membrane and storage glycerolipids through a series of endoplasmic …