The biology of the HIV-1 latent reservoir and implications for cure strategies
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
Current status of latency reversing agents facing the heterogeneity of HIV-1 cellular and tissue reservoirs
One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection
M Pardons, AE Baxter, M Massanella… - PLoS …, 2019 - journals.plos.org
The phenotypic characterization of the cells in which HIV persists during antiretroviral
therapy (ART) remains technically challenging. We developed a simple flow cytometry …
therapy (ART) remains technically challenging. We developed a simple flow cytometry …
Why and where an HIV cure is needed and how it might be achieved
Despite considerable global investment, only 60% of people who live with HIV currently
receive antiretroviral therapy. The sustainability of current programmes remains unknown …
receive antiretroviral therapy. The sustainability of current programmes remains unknown …
Phenotypic characterization of single CD4+ T cells harboring genetically intact and inducible HIV genomes
C Dufour, C Richard, M Pardons, M Massanella… - Nature …, 2023 - nature.com
The phenotype of the rare HIV-infected cells persisting during antiretroviral therapies (ART)
remains elusive. We developed a single-cell approach that combines the phenotypic …
remains elusive. We developed a single-cell approach that combines the phenotypic …
Resident memory T cells are a cellular reservoir for HIV in the cervical mucosa
J Cantero-Pérez, J Grau-Expósito… - Nature …, 2019 - nature.com
HIV viral reservoirs are established very early during infection. Resident memory T cells
(TRM) are present in tissues such as the lower female genital tract, but the contribution of …
(TRM) are present in tissues such as the lower female genital tract, but the contribution of …
Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir
The latent reservoir is a major barrier to HIV cure. As latently infected cells cannot be
phenotyped directly, the features of the in vivo reservoir have remained elusive. Here, we …
phenotyped directly, the features of the in vivo reservoir have remained elusive. Here, we …
Principles of immunotherapy: implications for treatment strategies in cancer and infectious diseases
The advances in cancer biology and pathogenesis during the past two decades, have
resulted in immunotherapeutic strategies that have revolutionized the treatment of …
resulted in immunotherapeutic strategies that have revolutionized the treatment of …
Anti-apoptotic protein BIRC5 maintains survival of HIV-1-infected CD4+ T cells
Summary HIV-1 infection of CD4+ T cells leads to cytopathic effects and cell demise, which
is counter to the observation that certain HIV-1-infected cells possess a remarkable long …
is counter to the observation that certain HIV-1-infected cells possess a remarkable long …
Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis
TA Olafsdottir, F Theodors, K Bjarnadottir… - Nature …, 2020 - nature.com
Asthma is one of the most common chronic diseases affecting both children and adults. We
report a genome-wide association meta-analysis of 69,189 cases and 702,199 controls from …
report a genome-wide association meta-analysis of 69,189 cases and 702,199 controls from …