Causes and consequences of RNA polymerase II stalling during transcript elongation
M Noe Gonzalez, D Blears, JQ Svejstrup - Nature reviews Molecular …, 2021 - nature.com
The journey of RNA polymerase II (Pol II) as it transcribes a gene is anything but a smooth
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
ride. Transcript elongation is discontinuous and can be perturbed by intrinsic regulatory …
Born to run: control of transcription elongation by RNA polymerase II
FX Chen, ER Smith, A Shilatifard - Nature reviews Molecular cell …, 2018 - nature.com
The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …
integral part of the implementation of gene expression programmes during development. In …
Getting up to speed with transcription elongation by RNA polymerase II
Recent advances in sequencing techniques that measure nascent transcripts and that
reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in …
reveal the positioning of RNA polymerase II (Pol II) have shown that the pausing of Pol II in …
Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut
NJ Proudfoot - Science, 2016 - science.org
BACKGROUND Genes correspond to single transcription units, starting from the promoter
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …
and ending at the terminator. Terminating gene transcription is directly coupled to mRNA …
[HTML][HTML] Mammalian NET-seq reveals genome-wide nascent transcription coupled to RNA processing
Transcription is a highly dynamic process. Consequently, we have developed native
elongating transcript sequencing technology for mammalian chromatin (mNET-seq), which …
elongating transcript sequencing technology for mammalian chromatin (mNET-seq), which …
Coupling mRNA processing with transcription in time and space
DL Bentley - Nature Reviews Genetics, 2014 - nature.com
Maturation of mRNA precursors often occurs simultaneously with their synthesis by RNA
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …
polymerase II (Pol II). The co-transcriptional nature of mRNA processing has permitted the …
Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans
Recent years have witnessed a sea change in our understanding of transcription regulation:
whereas traditional models focused solely on the events that brought RNA polymerase II …
whereas traditional models focused solely on the events that brought RNA polymerase II …
Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons
Production of mRNA depends critically on the rate of RNA polymerase II (Pol II) elongation.
To dissect Pol II dynamics in mouse ES cells, we inhibited Pol II transcription at either …
To dissect Pol II dynamics in mouse ES cells, we inhibited Pol II transcription at either …
[PDF][PDF] Integrator recruits protein phosphatase 2A to prevent pause release and facilitate transcription termination
Efficient release of promoter-proximally paused RNA Pol II into productive elongation is
essential for gene expression. Recently, we reported that the Integrator complex can bind …
essential for gene expression. Recently, we reported that the Integrator complex can bind …
Transcription termination and the control of the transcriptome: why, where and how to stop
O Porrua, D Libri - Nature reviews Molecular cell biology, 2015 - nature.com
Transcription termination occurs when the polymerase is released after a transcription event,
thus delimitating transcription units; however, the functional importance of termination …
thus delimitating transcription units; however, the functional importance of termination …