Ionizing radiation-induced epigenetic modifications and their relevance to radiation protection
M Belli, MA Tabocchini - International journal of molecular sciences, 2020 - mdpi.com
The present system of radiation protection assumes that exposure at low doses and/or low
dose-rates leads to health risks linearly related to the dose. They are evaluated by a …
dose-rates leads to health risks linearly related to the dose. They are evaluated by a …
Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications
IR Miousse, KR Kutanzi, I Koturbash - International journal of …, 2017 - Taylor & Francis
Purpose: Ionizing radiation (IR) is a ubiquitous environmental stressor with genotoxic and
epigenotoxic capabilities. Terrestrial IR, predominantly a low-linear energy transfer (LET) …
epigenotoxic capabilities. Terrestrial IR, predominantly a low-linear energy transfer (LET) …
Ionizing radiation and human health: Reviewing models of exposure and mechanisms of cellular damage. An epigenetic perspective
E Burgio, P Piscitelli, L Migliore - International journal of environmental …, 2018 - mdpi.com
We reviewed available evidence in medical literature concerning experimental models of
exposure to ionizing radiations (IR) and their mechanisms of producing damages on living …
exposure to ionizing radiations (IR) and their mechanisms of producing damages on living …
Response of transposable elements to environmental stressors
IR Miousse, MCG Chalbot, A Lumen… - … Research/Reviews in …, 2015 - Elsevier
Transposable elements (TEs) comprise a group of repetitive sequences that bring positive,
negative, as well as neutral effects to the host organism. Earlier considered as “junk DNA,” …
negative, as well as neutral effects to the host organism. Earlier considered as “junk DNA,” …
Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and …
JS Helm, RA Rudel - Archives of toxicology, 2020 - Springer
Abstract Knowledge about established breast carcinogens can support improved and
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …
Short-term exposure to engineered nanomaterials affects cellular epigenome
Extensive incorporation of engineered nanomaterials (ENMs) into industrial and biomedical
applications increases the risks of exposure to these potentially hazardous materials. While …
applications increases the risks of exposure to these potentially hazardous materials. While …
The epigenetic alterations of endogenous retroelements in aging
M Cardelli - Mechanisms of ageing and development, 2018 - Elsevier
Endogenous retroelements, transposons that mobilize through RNA intermediates, include
some of the most abundant repetitive sequences of the human genome, such as Alu and …
some of the most abundant repetitive sequences of the human genome, such as Alu and …
The role of environmental exposures and the epigenome in health and disease
The genetic material of every organism exists within the context of regulatory networks that
govern gene expression, collectively called the epigenome. Epigenetics has taken center …
govern gene expression, collectively called the epigenome. Epigenetics has taken center …
[HTML][HTML] Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic
NH Nicolay, RL Perez, R Saffrich, PE Huber - Oncotarget, 2015 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) comprise a heterogeneous population of multipotent
stromal cells and can be isolated from various tissues and organs. Due to their regenerative …
stromal cells and can be isolated from various tissues and organs. Due to their regenerative …
Concise review: the effect of low-dose ionizing radiation on stem cell biology: a contribution to radiation risk
T Squillaro, G Galano, R De Rosa, G Peluso… - Stem Cells, 2018 - academic.oup.com
Exposure to high levels of ionizing radiation (IR)(> 0.5 Gy) negatively affects health, but less
is known about the effects of low-dose ionizing radiation (LDIR). Recent evidence suggests …
is known about the effects of low-dose ionizing radiation (LDIR). Recent evidence suggests …