Ionizing radiation-induced epigenetic modifications and their relevance to radiation protection

M Belli, MA Tabocchini - International journal of molecular sciences, 2020 - mdpi.com
The present system of radiation protection assumes that exposure at low doses and/or low
dose-rates leads to health risks linearly related to the dose. They are evaluated by a …

Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications

IR Miousse, KR Kutanzi, I Koturbash - International journal of …, 2017 - Taylor & Francis
Purpose: Ionizing radiation (IR) is a ubiquitous environmental stressor with genotoxic and
epigenotoxic capabilities. Terrestrial IR, predominantly a low-linear energy transfer (LET) …

Ionizing radiation and human health: Reviewing models of exposure and mechanisms of cellular damage. An epigenetic perspective

E Burgio, P Piscitelli, L Migliore - International journal of environmental …, 2018 - mdpi.com
We reviewed available evidence in medical literature concerning experimental models of
exposure to ionizing radiations (IR) and their mechanisms of producing damages on living …

Response of transposable elements to environmental stressors

IR Miousse, MCG Chalbot, A Lumen… - … Research/Reviews in …, 2015 - Elsevier
Transposable elements (TEs) comprise a group of repetitive sequences that bring positive,
negative, as well as neutral effects to the host organism. Earlier considered as “junk DNA,” …

Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and …

JS Helm, RA Rudel - Archives of toxicology, 2020 - Springer
Abstract Knowledge about established breast carcinogens can support improved and
modernized toxicological testing methods by identifying key mechanistic events. Ionizing …

Short-term exposure to engineered nanomaterials affects cellular epigenome

X Lu, IR Miousse, SV Pirela, S Melnyk, I Koturbash… - …, 2016 - Taylor & Francis
Extensive incorporation of engineered nanomaterials (ENMs) into industrial and biomedical
applications increases the risks of exposure to these potentially hazardous materials. While …

The epigenetic alterations of endogenous retroelements in aging

M Cardelli - Mechanisms of ageing and development, 2018 - Elsevier
Endogenous retroelements, transposons that mobilize through RNA intermediates, include
some of the most abundant repetitive sequences of the human genome, such as Alu and …

The role of environmental exposures and the epigenome in health and disease

BPU Perera, C Faulk, LK Svoboda… - Environmental and …, 2020 - Wiley Online Library
The genetic material of every organism exists within the context of regulatory networks that
govern gene expression, collectively called the epigenome. Epigenetics has taken center …

[HTML][HTML] Radio-resistant mesenchymal stem cells: mechanisms of resistance and potential implications for the clinic

NH Nicolay, RL Perez, R Saffrich, PE Huber - Oncotarget, 2015 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) comprise a heterogeneous population of multipotent
stromal cells and can be isolated from various tissues and organs. Due to their regenerative …

Concise review: the effect of low-dose ionizing radiation on stem cell biology: a contribution to radiation risk

T Squillaro, G Galano, R De Rosa, G Peluso… - Stem Cells, 2018 - academic.oup.com
Exposure to high levels of ionizing radiation (IR)(> 0.5 Gy) negatively affects health, but less
is known about the effects of low-dose ionizing radiation (LDIR). Recent evidence suggests …