Chronic kidney disease
P Romagnani, G Remuzzi, R Glassock… - Nature reviews Disease …, 2017 - nature.com
Chronic kidney disease (CKD) is defined by persistent urine abnormalities, structural
abnormalities or impaired excretory renal function suggestive of a loss of functional …
abnormalities or impaired excretory renal function suggestive of a loss of functional …
[HTML][HTML] Klotho, aging, and the failing kidney
S Buchanan, E Combet, P Stenvinkel… - Frontiers in …, 2020 - frontiersin.org
Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …
30 years, where it regulates phosphate homeostasis and the activity of members of the …
[HTML][HTML] FGF23 signalling and physiology
BB Ho, C Bergwitz - Journal of molecular endocrinology, 2021 - jme.bioscientifica.com
Fibroblast growth factor 23 (FGF23) is a phosphotropic hormone that belongs to a subfamily
of endocrine FGFs with evolutionarily conserved functions in worms and fruit flies. FAM20C …
of endocrine FGFs with evolutionarily conserved functions in worms and fruit flies. FAM20C …
[HTML][HTML] The systemic nature of CKD
The accurate definition and staging of chronic kidney disease (CKD) is one of the major
achievements of modern nephrology. Intensive research is now being undertaken to unravel …
achievements of modern nephrology. Intensive research is now being undertaken to unravel …
[HTML][HTML] FGF23 and its role in X-linked hypophosphatemia-related morbidity
SS Beck-Nielsen, Z Mughal, D Haffner… - Orphanet Journal of …, 2019 - Springer
Background X-linked hypophosphatemia (XLH) is an inherited disease of phosphate
metabolism in which inactivating mutations of the Phosphate Regulating Endopeptidase …
metabolism in which inactivating mutations of the Phosphate Regulating Endopeptidase …
[HTML][HTML] Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease
Patients with chronic kidney disease (CKD) develop increased levels of the phosphate-
regulating hormone, fibroblast growth factor (FGF) 23, that are associated with a higher risk …
regulating hormone, fibroblast growth factor (FGF) 23, that are associated with a higher risk …
Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho
S Yamada, CM Giachelli - Bone, 2017 - Elsevier
Vascular calcification (VC) is highly prevalent in aging, diabetes mellitus, and chronic kidney
disease (CKD). VC is a strong predictor of cardiovascular morbidity and mortality in the CKD …
disease (CKD). VC is a strong predictor of cardiovascular morbidity and mortality in the CKD …
[HTML][HTML] Mineral bone disorders in kidney disease patients: the ever-current topic
L Hu, A Napoletano, M Provenzano, C Garofalo… - International Journal of …, 2022 - mdpi.com
Chronic kidney disease (CKD) is a complex and multifactorial disease, and one of the most
prevalent worldwide. Chronic kidney disease–mineral bone disorders (CKD–MBD) with …
prevalent worldwide. Chronic kidney disease–mineral bone disorders (CKD–MBD) with …
FGF23 and klotho at the intersection of kidney and cardiovascular disease
Cardiovascular disease is the leading cause of death in patients with chronic kidney disease
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …
The heart and vascular system in dialysis
C Wanner, K Amann, T Shoji - The Lancet, 2016 - thelancet.com
The heart and the vascular tree undergo major structural and functional changes when
kidney function declines and renal replacement therapy is required. The many …
kidney function declines and renal replacement therapy is required. The many …