Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Spermatogenesis is a concerted sequence of events during maturation of spermatogonia
into spermatozoa. The process involves differential gene-expression and cell-cell interplay …

Reactive oxygen species (ROS) have been extensively studied as a cause of male infertility.
Excessive levels of ROS coupled with a deficiency in antioxidants can lead to oxidative …

Activation of caspase, externalization of phosphatidyl serine, change in the mitochondrial
membrane potential, and DNA fragmentation are apoptosis markers found in human …

Reactive oxygen species (ROS) are free radicals derived from oxygen during normal cellular
metabolism. ROS play a crucial role in the physiological processes and signalling pathways …

Sperm DNA integrity is essential for the accurate transmission of genetic information. It has a
highly compact and complex structure and is capable of decondensation—features that must …

Reactive oxygen species (ROS) are known mediators of intracellular signal cascades.
Excessive production of ROS may lead to oxidative stress, loss of cell function, and cell …

BACKGROUND Mitochondria are multitasking organelles involved in ATP synthesis,
reactive oxygen species (ROS) production, calcium signalling and apoptosis; and …

Spermatogenesis is completely dependent on the pituitary hormone follicle-stimulating
hormone (FSH) and androgens locally produced in response to luteinising hormone (LH) …

Cellular apoptosis appears to be a constant feature in the adult testis and during early
development. This is essential because mammalian spermatogenesis is a complex process …