[HTML][HTML] NF-κB: blending metabolism, immunity, and inflammation
D Capece, D Verzella, I Flati, P Arboretto, J Cornice… - Trends in …, 2022 - cell.com
The procurement and management of nutrients and ability to fight infections are fundamental
requirements for survival. These defense responses are bioenergetically costly, requiring …
requirements for survival. These defense responses are bioenergetically costly, requiring …
The role of lipids in cancer progression and metastasis
M Martin-Perez, U Urdiroz-Urricelqui, C Bigas… - Cell metabolism, 2022 - cell.com
Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …
as a signaling molecule, and being a structural component of membranes); however, an …
The metabolism of cancer cells during metastasis
G Bergers, SM Fendt - Nature Reviews Cancer, 2021 - nature.com
Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …
extensive research, targeting metastatic seeding and colonization is still an unresolved …
Lipid metabolism in cancer: New perspectives and emerging mechanisms
LA Broadfield, AA Pane, A Talebi, JV Swinnen… - Developmental cell, 2021 - cell.com
Tumors undergo metabolic transformations to sustain uncontrolled proliferation, avoid cell
death, and seed in secondary organs. An increased focus on cancer lipid metabolism has …
death, and seed in secondary organs. An increased focus on cancer lipid metabolism has …
[HTML][HTML] Stem cell programs in cancer initiation, progression, and therapy resistance
Over the past few decades, substantial evidence has convincingly revealed the existence of
cancer stem cells (CSCs) as a minor subpopulation in cancers, contributing to an aberrantly …
cancer stem cells (CSCs) as a minor subpopulation in cancers, contributing to an aberrantly …
HCAR1/MCT1 regulates tumor ferroptosis through the lactate-mediated AMPK-SCD1 activity and its therapeutic implications
Y Zhao, M Li, X Yao, Y Fei, Z Lin, Z Li, K Cai, Y Zhao… - Cell reports, 2020 - cell.com
Ferroptosis is a recently discovered form of programed cell death caused by the
metabolically regulated lipid peroxidation and holds promise for cancer treatment, but its …
metabolically regulated lipid peroxidation and holds promise for cancer treatment, but its …
Greasing the wheels of the cancer machine: the role of lipid metabolism in cancer
MT Snaebjornsson, S Janaki-Raman, A Schulze - Cell metabolism, 2020 - cell.com
Altered lipid metabolism is among the most prominent metabolic alterations in cancer.
Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor …
Enhanced synthesis or uptake of lipids contributes to rapid cancer cell growth and tumor …
Lipid composition of the cancer cell membrane
Cancer cell possesses numerous adaptations to resist the immune system response and
chemotherapy. One of the most significant properties of the neoplastic cells is the altered …
chemotherapy. One of the most significant properties of the neoplastic cells is the altered …
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
Clear-cell carcinomas (CCCs) are a histological group of highly aggressive malignancies
commonly originating in the kidney and ovary. CCCs are distinguished by aberrant lipid and …
commonly originating in the kidney and ovary. CCCs are distinguished by aberrant lipid and …
Lung cancer scRNA-seq and lipidomics reveal aberrant lipid metabolism for early-stage diagnosis
Lung cancer is the leading cause of cancer mortality, and early detection is key to improving
survival. However, there are no reliable blood-based tests currently available for early-stage …
survival. However, there are no reliable blood-based tests currently available for early-stage …