Advances and perspectives in carrier-free nanodrugs for cancer chemo-monotherapy and combination therapy

L Huang, S Zhao, F Fang, T Xu, M Lan, J Zhang - Biomaterials, 2021 - Elsevier
Nanocarrier-based drug delivery systems hold impressive promise for biomedical
application because of their excellent water dispersibility, prolonged blood circulation time …

Polymeric nanoparticles for targeted treatment in oncology: current insights

RH Prabhu, VB Patravale, MD Joshi - International journal of …, 2015 - Taylor & Francis
Chemotherapy, a major strategy for cancer treatment, lacks the specificity to localize the
cancer therapeutics in the tumor site, thereby affecting normal healthy tissues and …

Chemistry of mesoporous organosilica in nanotechnology: molecularly organic–inorganic hybridization into frameworks

Y Chen, J Shi - Advanced Materials, 2016 - Wiley Online Library
Organic–inorganic hybrid materials aiming to combine the individual advantages of organic
and inorganic components while overcoming their intrinsic drawbacks have shown great …

Overcoming multidrug resistance in cancer: Recent progress in nanotechnology and new horizons

M Majidinia, M Mirza‐Aghazadeh‐Attari, M Rahimi… - IUBMB …, 2020 - Wiley Online Library
Multidrug resistance (MDR), defined as the ability of cancer cells to gain resistance to both
conventional and novel chemotherapy agents, is an important barrier in treating …

Nanodrug delivery in reversing multidrug resistance in cancer cells

S Kapse-Mistry, T Govender, R Srivastava… - Frontiers in …, 2014 - frontiersin.org
Different mechanisms in cancer cells become resistant to one or more chemotherapeutics is
known as multidrug resistance (MDR) which hinders chemotherapy efficacy. Potential …

[HTML][HTML] Understanding of human ATP binding cassette superfamily and novel multidrug resistance modulators to overcome MDR

IS Mohammad, W He, L Yin - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Indeed, multi-drug resistance (MDR) is a significant obstacle to effective chemotherapy. The
overexpression of ATP-binding cassette (ABC) membrane transporters is a principal cause …

Polymeric nanoparticles for nasal drug delivery to the brain: relevance to Alzheimer's disease

N Rabiee, S Ahmadi, R Afshari, S Khalaji… - Advanced …, 2021 - Wiley Online Library
Currently, Alzheimer's disease (AD) accounts for more than half of all dementia cases.
Although genetics, age, and environmental factors affect the disease, the cause of AD is not …

Overcoming multidrug resistance in cancer stem cells

K Moitra - BioMed research international, 2015 - Wiley Online Library
The principle mechanism of protection of stem cells is through the expression of ATP‐
binding cassette (ABC) transporters. These transporters serve as the guardians of the stem …

The new era of nanotechnology, an alternative to change cancer treatment

A Jurj, C Braicu, LA Pop, C Tomuleasa… - Drug design …, 2017 - Taylor & Francis
In the last few years, nanostructures have gained considerable interest for the safe delivery
of therapeutic agents. Several therapeutic approaches have been reported, such as …

Nanomedicinal strategies to treat multidrug-resistant tumors: current progress

X Dong, RJ Mumper - Nanomedicine, 2010 - Taylor & Francis
Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. P-
glycoprotein is an important and the best-known membrane transporter involved in MDR …