Preeclampsia evolves in 2 stages: a placental problem that generates signals to the mother
to cause a range of responses that comprise the second stage (preeclampsia syndrome) …

Pre-eclampsia is a common disorder that particularly affects first pregnancies. The clinical
presentation is highly variable but hypertension and proteinuria are usually seen. These …

Placental-related fetal growth restriction arises primarily due to deficient remodeling of the
uterine spiral arteries supplying the placenta during early pregnancy. The resultant …

The role of oxidative stress in the physiopathology of human pregnancy is of particular
interest. Pregnancy is well-known to increase the oxidative stress, mainly produced by a …

Preeclampsia is a pregnancy-specific syndrome with multisystem involvement which leads
to foetal, neonatal, and maternal morbidity and mortality. This syndrome is characterized by …

Maternal obesity is associated with pregnancy complications and increases the risk for the
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …

BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

The recent outbreak of Zika virus (ZIKV) was associated with birth defects and pregnancy
loss when maternal infection occurs in early pregnancy, but specific mechanisms driving …

Mitochondria are central to cell function. The placenta forms the interface between maternal
and fetal systems, and placental mitochondria have critical roles in maintaining pregnancy …

Background It is well established that obesity is associated with dysregulation of the ratio
between the two major adipokines leptin and adiponectin. Furthermore, it was recently …