Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …

Normal cardiac function requires that intracellular Ca2+ concentration be reduced to low
levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often …

Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …

Hypertension plays a major role in the development and progression of micro-and
macrovascular disease. Moreover, increased blood pressure often coexists with additional …

Diabetes is a common chronic metabolic disease, and its incidence continues to increase
year after year. Diabetic patients mainly die from various complications, with the most …

Diabetes mellitus significantly increases the risk of cardiovascular disease and heart failure
in patients. Independent of hypertension and coronary artery disease, diabetes is associated …

Abnormality in myocardial copper homeostasis is believed to contribute to the development
of cardiomyopathy. Trientine, a copper-chelating drug used in the management of patients …

Myocardial regeneration is the key to the functional recovery of ischemic heart.
Angiogenesis plays a pivotal role in myocardial regeneration by resetting a rejuvenation …

Diabetes mellitus (DM) is a chronic metabolic disorder commonly characterized by high
blood glucose levels, resulting from defects in insulin production or insulin resistance, or …

Pressure overload causes an accumulation of homocysteine in the heart, which is
accompanied by copper depletion through the formation of copper–homocysteine …