Immunoglobulin E (IgE) antibodies are well known for their role in mediating allergic
reactions, and their powerful effector functions activated through binding to Fc receptors …

Recombinant proteins offer many therapeutic advantages unavailable in traditional small
molecule drugs, but the need for cellular versus chemical synthesis complicates production …

Cysteine can be specifically functionalized by a myriad of acid-base conjugation strategies
for applications ranging from probing protein function to antibody-drug conjugates and …

In contrast to a second dose of the SARS-CoV-2 mRNA vaccine, a third dose elicits potent
neutralizing activity against the Omicron variant. To address the underlying mechanism for …

Methods to identify genes encoding immunoglobulin heavy and light chains from single B
lymphocytes vary in efficiency, error rate and practicability. Here we describe a protocol to …

A still unanswered question is what drives the small fraction of activated germinal center
(GC) B cells to become long-lived quiescent memory B cells. We found here that a small …

SARS-CoV-2 continues to evolve into variants of concern (VOC), with greatest variability in
the multidomain, entry-facilitating spike proteins. To recognize the significance of adaptive …

Fifty-eight million individuals worldwide are affected by chronic hepatitis C virus (HCV)
infection, a primary driver of liver cancer for which no vaccine is available. The HCV …

Recombinant expression of antibody molecules in mammalian cells offers important
advantages over traditionally utilized bacterial expression, including glycosylation required …

Monoclonal antibodies are increasingly used to prevent and treat viral infections and are
pivotal in pandemic response efforts. Antibody-secreting cells (ASCs; plasma cells and …