Studies were conducted on the hypothesis that melanoma metastasis might be initiated
through the gener-ation of hybrids comprised of cells of the primary tumor and tumor …

Recently, many surface proteins of lymphoid cells that mediate adhesion to other cells and
extracellular matrix have been identified. Several of these cellular adhesion molecules …

Lymphocyte function-associated antigen-1 (LFA-1) is a leukocyte and lymphoma cell surface
protein that promotes intercellular adhesion. We have previously shown that the invasion of …

Dissemination of T cell hybridomas in mice, a model for in vivo migration of memory T cells
and for T lymphoma metastasis, depends on the chemokine stromal cell-derived factor-1 …

Lymphomas are common malignancies that are prevalent worldwide. In recent years, some
types of lymphoma have become curable, but relapsed and refractory lymphomas remain …

The dissemination of T cell hybridomas to multiple nonhematopoietic tissues is blocked by
pertussis toxin, suggesting the involvement of a chemokine. To study whether this …

The ZAP-70 tyrosine kinase is essential for T cell activation by the T cell receptor. We show
that ZAP-70 is also required for migration of T cells that is dependent on the integrin LFA-1 …

We previously showed that LFA-1-dependent in vitro invasion and in vivo migration of a T
cell hybridoma was blocked in cells overexpressing a truncated dominant-negative ζ …

Abstract The Membrane Invasion Culture System (MICS) assay was adapted for relatively
rapid screening of compounds and used to identify anti‐invasive drugs that inhibit human …

Synaptotagmins regulate vesicle trafficking and fusion of vesicles with membranes–
processes that have been implicated in cell migration. We therefore hypothesized that …