In-vitro models of biocompatibility testing for restorative dental materials: From 2D cultures to organs on-a-chip
CM Franca, G de Souza Balbinot, D Cunha… - Acta biomaterialia, 2022 - Elsevier
Dental caries is a biofilm-mediated, diet-modulated, multifactorial and dynamic disease that
affects more than 90% of adults in Western countries. The current treatment for decayed …
affects more than 90% of adults in Western countries. The current treatment for decayed …
The application of organs-on-a-chip in dental, oral, and craniofacial research
C Huang, F Sanaei, WPR Verdurmen… - Journal of dental …, 2023 - journals.sagepub.com
The current development of microfluidics-based microphysiological systems (MPSs) will
rapidly lead to a paradigm shift from traditional static 2-dimensional cell cultivation towards …
rapidly lead to a paradigm shift from traditional static 2-dimensional cell cultivation towards …
Microphysiological Modeling of Gingival Tissues and Host‐Material Interactions Using Gingiva‐on‐Chip
G Muniraj, RHS Tan, Y Dai, R Wu… - Advanced …, 2023 - Wiley Online Library
Gingiva plays a crucial barrier role at the interface of teeth, tooth‐supporting structures,
microbiome, and external agents. To mimic this complex microenvironment, an in vitro …
microbiome, and external agents. To mimic this complex microenvironment, an in vitro …
Oral mucositis on a chip: Modeling induction by chemo-and radiation treatments and recovery
Oral mucositis (OM) is a debilitating complication affecting roughly 70% of head and neck
cancer patients receiving chemotherapy and/or radiation treatment. No broadly effective …
cancer patients receiving chemotherapy and/or radiation treatment. No broadly effective …
Alternatives of animal models for biomedical research: a comprehensive review of modern approaches
A Vashishat, P Patel, G Das Gupta… - Stem Cell Reviews and …, 2024 - Springer
Biomedical research has long relied on animal models to unravel the intricacies of human
physiology and pathology. However, concerns surrounding ethics, expenses, and inherent …
physiology and pathology. However, concerns surrounding ethics, expenses, and inherent …
A physiologically relevant culture platform for long-term studies of in vitro gingival tissue
There is a clinical need to understand the etiologies of periodontitis, considering the growing
socio-economic impact of the disease. Despite recent advances in oral tissue engineering …
socio-economic impact of the disease. Despite recent advances in oral tissue engineering …
Three‐Dimensional Humanized Model of the Periodontal Gingival Pocket to Study Oral Microbiome
M Adelfio, Z Martin‐Moldes, J Erndt‐Marino… - Advanced …, 2023 - Wiley Online Library
The oral cavity contains distinct microenvironments that serve as oral barriers, such as the
non‐shedding surface of the teeth (eg, enamel), the epithelial mucosa and gingival tissue …
non‐shedding surface of the teeth (eg, enamel), the epithelial mucosa and gingival tissue …
Flow-assembled chitosan membranes in microfluidics: recent advances and applications
The integration of membranes in microfluidic devices has been extensively exploited for
various chemical engineering and bioengineering applications over the past few decades …
various chemical engineering and bioengineering applications over the past few decades …
A microfluidic organ-on-a-chip: into the next decade of bone tissue engineering applied in dentistry
A comprehensive understanding of the complex physiological and pathological processes
associated with alveolar bones, their responses to different therapeutics strategies, and cell …
associated with alveolar bones, their responses to different therapeutics strategies, and cell …
Biofabrication Strategies for Oral Soft Tissue Regeneration
Gingival recession, a prevalent condition affecting the gum tissues, is characterized by the
exposure of tooth root surfaces due to the displacement of the gingival margin. This review …
exposure of tooth root surfaces due to the displacement of the gingival margin. This review …