In-vitro models of biocompatibility testing for restorative dental materials: From 2D cultures to organs on-a-chip

CM Franca, G de Souza Balbinot, D Cunha… - Acta biomaterialia, 2022 - Elsevier
Dental caries is a biofilm-mediated, diet-modulated, multifactorial and dynamic disease that
affects more than 90% of adults in Western countries. The current treatment for decayed …

The application of organs-on-a-chip in dental, oral, and craniofacial research

C Huang, F Sanaei, WPR Verdurmen… - Journal of dental …, 2023 - journals.sagepub.com
The current development of microfluidics-based microphysiological systems (MPSs) will
rapidly lead to a paradigm shift from traditional static 2-dimensional cell cultivation towards …

Microphysiological Modeling of Gingival Tissues and Host‐Material Interactions Using Gingiva‐on‐Chip

G Muniraj, RHS Tan, Y Dai, R Wu… - Advanced …, 2023 - Wiley Online Library
Gingiva plays a crucial barrier role at the interface of teeth, tooth‐supporting structures,
microbiome, and external agents. To mimic this complex microenvironment, an in vitro …

Oral mucositis on a chip: Modeling induction by chemo-and radiation treatments and recovery

KL Ly, X Luo, CB Raub - Biofabrication, 2022 - iopscience.iop.org
Oral mucositis (OM) is a debilitating complication affecting roughly 70% of head and neck
cancer patients receiving chemotherapy and/or radiation treatment. No broadly effective …

Alternatives of animal models for biomedical research: a comprehensive review of modern approaches

A Vashishat, P Patel, G Das Gupta… - Stem Cell Reviews and …, 2024 - Springer
Biomedical research has long relied on animal models to unravel the intricacies of human
physiology and pathology. However, concerns surrounding ethics, expenses, and inherent …

A physiologically relevant culture platform for long-term studies of in vitro gingival tissue

M Adelfio, M Bonzanni, GE Callen, BJ Paster… - Acta biomaterialia, 2023 - Elsevier
There is a clinical need to understand the etiologies of periodontitis, considering the growing
socio-economic impact of the disease. Despite recent advances in oral tissue engineering …

Three‐Dimensional Humanized Model of the Periodontal Gingival Pocket to Study Oral Microbiome

M Adelfio, Z Martin‐Moldes, J Erndt‐Marino… - Advanced …, 2023 - Wiley Online Library
The oral cavity contains distinct microenvironments that serve as oral barriers, such as the
non‐shedding surface of the teeth (eg, enamel), the epithelial mucosa and gingival tissue …

Flow-assembled chitosan membranes in microfluidics: recent advances and applications

KL Ly, P Hu, X Luo - Journal of Materials Chemistry B, 2021 - pubs.rsc.org
The integration of membranes in microfluidic devices has been extensively exploited for
various chemical engineering and bioengineering applications over the past few decades …

A microfluidic organ-on-a-chip: into the next decade of bone tissue engineering applied in dentistry

MH Syahruddin, R Anggraeni, ID Ana - Future Science OA, 2023 - Taylor & Francis
A comprehensive understanding of the complex physiological and pathological processes
associated with alveolar bones, their responses to different therapeutics strategies, and cell …

Biofabrication Strategies for Oral Soft Tissue Regeneration

M Rahimnejad, H Makkar, R Dal‐Fabbro… - Advanced …, 2024 - Wiley Online Library
Gingival recession, a prevalent condition affecting the gum tissues, is characterized by the
exposure of tooth root surfaces due to the displacement of the gingival margin. This review …