Local anesthetics, which cause temporary loss of pain by inhibiting the transmission of nerve
impulses, have been widely used in clinical practice. However, neurotoxicity and short half …

Low encapsulation efficiency of the drug usually exist in hydrophilic drug which was
embedded by hydrophobic materials directly in traditional method. In order to solve this …

This study reports the development of nanostructured hydrogels for the sustained release of
the eutectic mixture of lidocaine and prilocaine (both at 2.5%) for intraoral topical use. The …

Nanostructured lipid carriers (NLCs) have gained significant attention as tools for the dermal
delivery of therapeutics due to their stability, biocompatibility, and ability to improve drug …

Ropivacaine loaded microspheres offer an attractive alternative for prolonging the duration
of local anesthetics for the pain management. However, traditional microcapsulation …

Wound healing materials to prevent blood loss are crucial during emergency medical
treatment because uncontrolled bleeding can lead to patient death. Herein, bioabsorbable …

Background Poly (amidoamine)(PAMAM) dendrimers are of considerable interest when
used as a carrier for topical drugs for the skin, although little is known about their possible …

This review attempted to ascertain the rationale for the formulation of sustained-release local
anesthetics and summarize the various formulation approaches designed to date to achieve …

Bupivacaine hydrochloride (BVC) represents an option to produce long-lasting analgesia,
and complexation in cyclodextrins has shown improvements in biopharmaceutical …

Peripheral nerve blockade (PNB) is a common treatment to relieve postoperative pain.
However, local anesthetics alone have a short duration of action and severe side effects …