Brain metastases

AS Achrol, RC Rennert, C Anders, R Soffietti… - Nature Reviews …, 2019 - nature.com
An estimated 20% of all patients with cancer will develop brain metastases, with the majority
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …

[HTML][HTML] Brain malignancies: Glioblastoma and brain metastases

TT Lah, M Novak, B Breznik - Seminars in cancer biology, 2020 - Elsevier
Brain, the major organ of the central nervous system controls and processes most of body
activities. Therefore, the most aggressive brain tumor–glioblastoma and metastases from …

The calcium–cancer signalling nexus

GR Monteith, N Prevarskaya… - Nature Reviews …, 2017 - nature.com
The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced …

Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma

L De Mattos-Arruda, R Mayor, CKY Ng… - Nature …, 2015 - nature.com
Cell-free circulating tumour DNA (ctDNA) in plasma has been shown to be informative of the
genomic alterations present in tumours and has been used to monitor tumour progression …

Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities

N Cosgrove, D Varešlija, S Keelan, A Elangovan… - Nature …, 2022 - nature.com
The molecular events and transcriptional plasticity driving brain metastasis in clinically
relevant breast tumor subtypes has not been determined. Here we comprehensively dissect …

The evolving landscape of brain metastasis

M Valiente, MS Ahluwalia, A Boire, PK Brastianos… - Trends in cancer, 2018 - cell.com
Metastasis, involving the spread of systemic cancer to the brain, results in neurologic
disability and death. Current treatments are largely palliative in nature; improved therapeutic …

Molecular and cellular mechanisms underlying brain metastasis of breast cancer

M Hosonaga, H Saya, Y Arima - Cancer and Metastasis Reviews, 2020 - Springer
Metastasis of cancer cells to the brain occurs frequently in patients with certain subtypes of
breast cancer. In particular, patients with HER2-positive or triple-negative breast cancer are …

[HTML][HTML] Calcium signaling and the therapeutic targeting of cancer cells

AHL Bong, GR Monteith - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
The calcium signal is implicated in a variety of processes important in tumor progression (eg
proliferation and invasiveness). The calcium signal has also been shown to be important in …

Mechanisms and therapy for cancer metastasis to the brain

F Franchino, R Rudà, R Soffietti - Frontiers in oncology, 2018 - frontiersin.org
Advances in chemotherapy and targeted therapies have improved survival in cancer
patients with an increase of the incidence of newly diagnosed brain metastases (BMs) …

HER2‐positive breast cancer brain metastasis: a new and exciting landscape

AS Zimmer, AED Van Swearingen… - Cancer …, 2022 - Wiley Online Library
Abstract Background Brain metastases (BrM) incidence is 25% to 50% in women with
advanced human epidermal growth factor receptor 2 (HER2)‐positive breast cancer …