NMR studies of ligand binding to dihydrofolate reductase

J Feeney - Angewandte Chemie International Edition, 2000 - Wiley Online Library
Unique capabilities are offered by NMR spectroscopy for probing specific interactions of
enzymes with substrates and substrate analogues, for characterizing the multiple …

Solution structure of an EGF module pair from the Plasmodium falciparum merozoite surface protein 1

WD Morgan, B Birdsall, TA Frenkiel… - Journal of molecular …, 1999 - Elsevier
The solution structure of the 96-residue C-terminal fragment of the merozoite surface protein
1 (MSP-1) from Plasmodium falciparum has been determined using nuclear magnetic …

Self-Consistent Karplus Parametrization of 3J Couplings Depending on the Polypeptide Side-Chain Torsion χ1

C Pérez, F Löhr, H Rüterjans… - Journal of the American …, 2001 - ACS Publications
Recently proposed self-consistent 3 J coupling analysis (Schmidt, JM; Blümel, M.; Löhr, F.;
Rüterjans, HJ Biomol. NMR 1999, 14, 1− 12) has been carried out to calibrate Karplus …

Automated structure determination of proteins by NMR spectroscopy

W Gronwald, HR Kalbitzer - Progress in Nuclear Magnetic Resonance …, 2004 - Elsevier
Contents 1. Introduction............................................................................. 33 1.1. Automated
structure determination methods in the postgenomics area.............................. 34 2. Automated …

[HTML][HTML] NMR solution structure of rat Aβ (1–16): toward understanding the mechanism of rats' resistance to Alzheimer's disease

AN Istrate, PO Tsvetkov, AB Mantsyzov, AA Kulikova… - Biophysical journal, 2012 - cell.com
In an attempt to reveal the mechanism of rats' resistance to Alzheimer's disease, we
determined the structure of the metal-binding domain 1–16 of rat β-amyloid (rat Aβ (1–16)) in …

High-resolution solution structure of human pNR-2/pS2: a single trefoil motif protein

VI Polshakov, MA Williams, AR Gargaro… - Journal of molecular …, 1997 - Elsevier
pNR-2/pS2 is a 60 residue extracellular protein, which was originally discovered in human
breast cancer cells, and subsequently found in other tumours and normal gastric epithelial …

Solution Structures of the C-Terminal Domain of Cardiac Troponin C Free and Bound to the N-Terminal Domain of Cardiac Troponin I,

GMC Gasmi-Seabrook, JW Howarth, N Finley… - Biochemistry, 1999 - ACS Publications
The N-terminal domain of cardiac troponin I (cTnI) comprising residues 33− 80 and lacking
the cardiac-specific amino terminus forms a stable binary complex with the C-terminal …

Conformational analysis of protein and nucleic acid fragments with the new grid search algorithm FOUND

P Güntert, M Billeter, O Ohlenschläger… - Journal of biomolecular …, 1998 - Springer
The new computer algorithm FOUND, which is implemented as an integrated module of the
DYANA structure calculation program, is capable of performing systematic local …

The solution structure of the complex of Lactobacillus casei dihydrofolate reductase with methotrexate

AR Gargaro, A Soteriou, TA Frenkiel, CJ Bauer… - Journal of molecular …, 1998 - Elsevier
We have determined the three-dimensional solution structure of the complex of
Lactobacillus casei dihydrofolate reductase (18.3 kDa, 162 amino acid residues) formed …

NMR solution structure and function of the C‐terminal domain of eukaryotic class 1 polypeptide chain release factor

AB Mantsyzov, EV Ivanova, B Birdsall… - The FEBS …, 2010 - Wiley Online Library
Termination of translation in eukaryotes is triggered by two polypeptide chain release
factors, eukaryotic class 1 polypeptide chain release factor (eRF1) and eukaryotic class 2 …