Since the birth of Louise Brown in 1978 via IVF, reproductive specialists have acquired
enormous knowledge and refined several procedures, which are nowadays applied in …

Many different lifestyle factors and chemicals present in the environment are a threat to the
reproductive tracts of humans. The potential for parental preconception exposure to alter …

Although male infertility is currently diagnosed when abnormal sperm parameters are found,
the poor predictive ability of sperm parameters on natural fecundity and medically assisted …

Spermatogenesis, a key part of the spermiation process, is regulated by a combination of
key cells, such as primordial germ cells, spermatogonial stem cells, and somatic cells, such …

Assisted reproductive technology may influence epigenetic signature as the procedures
coincide with the extensive epigenetic modification occurring from fertilization to embryo …

Fertility preservation via biobanking of testicular tissue retrieved from testicular biopsies is
now generally recommended for boys who need to undergo gonadotoxic treatment prior to …

Spermatogenesis is the process of generation of male reproductive cells from
spermatogonial stem cells in the seminiferous epithelium of the testis. During …

DNA methylation is one of the key epigenetic regulatory mechanisms in development and
spermatogenesis. However, the dynamic regulatory mechanisms of genome-wide DNA …

So far there has been no comprehensive review using systematic literature search strategies
to show the application of single-cell RNA sequencing (scRNA-seq) in the human testis of …

Male factor infertility affects 50% of infertile couples worldwide; the most severe form, non-
obstructive azoospermia (NOA), affects 10–15% of infertile males. Treatment for individuals …