[HTML][HTML] Drug repurposing for schistosomiasis: combinations of drugs or biomolecules

MJ Gouveia, PJ Brindley, F Gärtner, JMC Costa… - Pharmaceuticals, 2018 - mdpi.com
Schistosomiasis is a major neglected tropical disease. Control of schistosomiasis currently
relies on a single drug, praziquantel, and despite its efficacy against the all schistosome …

[HTML][HTML] N-acetyl-cysteine exhibits potent anti-mycobacterial activity in addition to its known anti-oxidative functions

EP Amaral, EL Conceição, DL Costa, MS Rocha… - BMC microbiology, 2016 - Springer
Background Mycobacterium tuberculosis infection is thought to induce oxidative stress. N-
acetyl-cysteine (NAC) is widely used in patients with chronic pulmonary diseases including …

Targeting thioredoxin glutathione reductase as a potential antischistosomal drug target

AF Eweas, G Allam - Molecular and biochemical parasitology, 2018 - Elsevier
Schistosomiasis represents a world health major problem affecting more than 206 million
people worldwide. Up to date, praziquantel (PZQ) is the sole chemotherapeutic agent used …

Effects of the probiotic Bacillus cereus GM on experimental schistosomiasis mansoni

VHB Dos Santos, ECP de Azevedo Ximenes… - Parasitology …, 2024 - Springer
Probiotics contribute to the integrity of the intestinal mucosa and preventing dysbiosis
caused by opportunistic pathogens, such as intestinal helminths. Bacillus cereus GM …

Schistosomicidal, hepatoprotective and antioxidant activities of the N-acetyl-L-cysteine and/or praziquantel in experimental acute mansonic schistosomiasis

A de Lima Aires, HDA De Araújo, AM Galvão… - 3 Biotech, 2023 - Springer
Schistosomiasis is a tropical parasitic disease, in which the major clinical manifestation
includes hepatosplenomegaly, portal hypertension, and organs fibrosis. Clinically, treatment …

β-Lapachone: a naphthoquinone with promising antischistosomal properties in mice

A de Lima Aires, ECPA Ximenes, VX Barbosa… - Phytomedicine, 2014 - Elsevier
The activity of β-lapachone (3, 4-dihydro-2, 2-dimethyl-2H-naphthol [1, 2-b] pyran-5, 6-dione,
β-lap) against different stages of Schistosoma mansoni was investigated in mice. Mice …

In vivo schistosomicidal activity of three novels 8-hydroxyquinoline derivatives against adult and immature worms of Schistosoma mansoni

G Allam, AF Eweas, ASA Abuelsaad - Parasitology Research, 2013 - Springer
Schistosomiasis control is widely dependent on a single drug, praziquantel (PZQ). The
potential for development of resistance to PZQ has justified the search for new alternative …

Fluorescent quantum dot-based nanotool for targeted identification and evaluation of the schistosomiasis circulating cathodic antigen in tissue samples

RRM Lima, MSS Pontes, MG Silva, JFF Ribeiro… - Micron, 2024 - Elsevier
Schistosomiasis represents a serious public health problem, a disease for which the
circulating cathodic antigen (CCA) is a relevant biomarker. Quantum dots (QDs) are …

[HTML][HTML] Current and novel therapies against helminthic infections: The potential of antioxidants combined with drugs

N Vale, MJ Gouveia, F Gärtner - Biomolecules, 2020 - mdpi.com
Infections caused by Schistosoma haematobium and Opisthorchis viverrini are classified as
Group 1 biological carcinogen and it has been postulated that parasites produce oxysterol …

Immunomodulatory and ameliorative role of Nigella sativa oil on Schistosoma mansoni infected mice.

SK Sheir, AMM Omayma, AH Mohamed, GY Osman… - 2015 - cabidigitallibrary.org
Schistosomiasis is one of the world's most prevalent parasitic diseases and cause of
morbidity and mortality. The present study was designed to investigate the immune …