[HTML][HTML] Drug repurposing for schistosomiasis: combinations of drugs or biomolecules
MJ Gouveia, PJ Brindley, F Gärtner, JMC Costa… - Pharmaceuticals, 2018 - mdpi.com
Schistosomiasis is a major neglected tropical disease. Control of schistosomiasis currently
relies on a single drug, praziquantel, and despite its efficacy against the all schistosome …
relies on a single drug, praziquantel, and despite its efficacy against the all schistosome …
[HTML][HTML] N-acetyl-cysteine exhibits potent anti-mycobacterial activity in addition to its known anti-oxidative functions
Background Mycobacterium tuberculosis infection is thought to induce oxidative stress. N-
acetyl-cysteine (NAC) is widely used in patients with chronic pulmonary diseases including …
acetyl-cysteine (NAC) is widely used in patients with chronic pulmonary diseases including …
Targeting thioredoxin glutathione reductase as a potential antischistosomal drug target
Schistosomiasis represents a world health major problem affecting more than 206 million
people worldwide. Up to date, praziquantel (PZQ) is the sole chemotherapeutic agent used …
people worldwide. Up to date, praziquantel (PZQ) is the sole chemotherapeutic agent used …
Effects of the probiotic Bacillus cereus GM on experimental schistosomiasis mansoni
VHB Dos Santos, ECP de Azevedo Ximenes… - Parasitology …, 2024 - Springer
Probiotics contribute to the integrity of the intestinal mucosa and preventing dysbiosis
caused by opportunistic pathogens, such as intestinal helminths. Bacillus cereus GM …
caused by opportunistic pathogens, such as intestinal helminths. Bacillus cereus GM …
Schistosomicidal, hepatoprotective and antioxidant activities of the N-acetyl-L-cysteine and/or praziquantel in experimental acute mansonic schistosomiasis
A de Lima Aires, HDA De Araújo, AM Galvão… - 3 Biotech, 2023 - Springer
Schistosomiasis is a tropical parasitic disease, in which the major clinical manifestation
includes hepatosplenomegaly, portal hypertension, and organs fibrosis. Clinically, treatment …
includes hepatosplenomegaly, portal hypertension, and organs fibrosis. Clinically, treatment …
β-Lapachone: a naphthoquinone with promising antischistosomal properties in mice
A de Lima Aires, ECPA Ximenes, VX Barbosa… - Phytomedicine, 2014 - Elsevier
The activity of β-lapachone (3, 4-dihydro-2, 2-dimethyl-2H-naphthol [1, 2-b] pyran-5, 6-dione,
β-lap) against different stages of Schistosoma mansoni was investigated in mice. Mice …
β-lap) against different stages of Schistosoma mansoni was investigated in mice. Mice …
In vivo schistosomicidal activity of three novels 8-hydroxyquinoline derivatives against adult and immature worms of Schistosoma mansoni
Schistosomiasis control is widely dependent on a single drug, praziquantel (PZQ). The
potential for development of resistance to PZQ has justified the search for new alternative …
potential for development of resistance to PZQ has justified the search for new alternative …
Fluorescent quantum dot-based nanotool for targeted identification and evaluation of the schistosomiasis circulating cathodic antigen in tissue samples
RRM Lima, MSS Pontes, MG Silva, JFF Ribeiro… - Micron, 2024 - Elsevier
Schistosomiasis represents a serious public health problem, a disease for which the
circulating cathodic antigen (CCA) is a relevant biomarker. Quantum dots (QDs) are …
circulating cathodic antigen (CCA) is a relevant biomarker. Quantum dots (QDs) are …
[HTML][HTML] Current and novel therapies against helminthic infections: The potential of antioxidants combined with drugs
N Vale, MJ Gouveia, F Gärtner - Biomolecules, 2020 - mdpi.com
Infections caused by Schistosoma haematobium and Opisthorchis viverrini are classified as
Group 1 biological carcinogen and it has been postulated that parasites produce oxysterol …
Group 1 biological carcinogen and it has been postulated that parasites produce oxysterol …
Immunomodulatory and ameliorative role of Nigella sativa oil on Schistosoma mansoni infected mice.
Schistosomiasis is one of the world's most prevalent parasitic diseases and cause of
morbidity and mortality. The present study was designed to investigate the immune …
morbidity and mortality. The present study was designed to investigate the immune …