Advanced maternal age in IVF: still a challenge? The present and the future of its treatment

FM Ubaldi, D Cimadomo, A Vaiarelli… - Frontiers in …, 2019 - frontiersin.org
Advanced maternal age (AMA;> 35 year) is associated with a decline in both ovarian
reserve and oocyte competence. At present, no remedies are available to counteract the …

Transcriptomic integrity of human oocytes used in ARTs: technical and intrinsic factor effects

B Ducreux, C Patrat, J Trasler… - Human Reproduction …, 2024 - academic.oup.com
Background Millions of children have been born throughout the world thanks to ARTs, the
harmlessness of which has not yet been fully demonstrated. For years, efforts to evaluate the …

Bioinspired l-Proline Oligomers for the Cryopreservation of Oocytes via Controlling Ice Growth

Q Qin, L Zhao, Z Liu, T Liu, J Qu, X Zhang… - … applied materials & …, 2020 - ACS Publications
Various types of cells are routinely cryopreserved in modern regenerative and cell-based
medicines. For instance, the oocyte is one of the most demanding cells to be cryopreserved …

The role of Hippo pathway in ovarian development

M Zhu, M Xu, J Zhang, C Zheng - Frontiers in Physiology, 2023 - frontiersin.org
The follicle is the functional unit of the ovary, whereby ovarian development is largely
dependent on the development of the follicles themselves. The activation, growth, and …

Melatonin protects mitochondrial function and inhibits oxidative damage against the decline of human oocytes development caused by prolonged cryopreservation

Q Zhu, D Ding, H Yang, W Zou, D Yang, K Wang… - Cells, 2022 - mdpi.com
Melatonin (MT) can improve the effect of cryopreservation on oocytes by suppressing
oxidative stress and maintaining the permeability of the oolemma. In this study, MT was …

[HTML][HTML] Planned oocyte cryopreservation: the state of the ART

SD Cascante, AS Berkeley, F Licciardi… - Reproductive …, 2023 - Elsevier
The objective of this review is to provide an update on planned oocyte cryopreservation.
This fertility preservation method increases reproductive autonomy by allowing women to …

State of the art on oocyte cryopreservation in female cancer patients: a critical review of the literature

C Massarotti, P Scaruffi, M Lambertini… - Cancer treatment …, 2017 - Elsevier
During the last decades, important advances in therapeutic options have led to increased
survival rates in cancer patients; however, cancer treatments are associated with several …

Effects of vitrification and cryostorage duration on single-cell RNA-Seq profiling of vitrified-thawed human metaphase II oocytes

Y Huo, P Yuan, Q Qin, Z Yan, L Yan, P Liu, R Li… - Frontiers of …, 2021 - Springer
Oocyte cryopreservation is widely used for clinical and social reasons. Previous studies
have demonstrated that conventional slow-freezing cryopreservation procedures, but not …

Can Cryopreservation in assisted Reproductive Technology (ART) induce epigenetic changes to gametes and embryos?

R Sciorio, C Manna, P Fauque, P Rinaudo - Journal of Clinical Medicine, 2023 - mdpi.com
Since the birth of Louise Brown in 1978, more than nine million children have been
conceived using assisted reproductive technologies (ARTs). While the great majority of …

Elective oocyte cryopreservation for age-related fertility decline

E Chronopoulou, C Raperport, A Sfakianakis… - Journal of Assisted …, 2021 - Springer
Purpose Women who pursue fertility at an advanced age are increasingly common. Family
planning and sexual education have traditionally focused on contraception and prevention …