Background: Sepsis is a deadly immunological disorder and its pathophysiology is still
poorly understood. We aimed to determine if specific pro-inflammatory and anti-inflammatory …

Sepsis is the most frequent cause of death in non-coronary intensive care units (ICUs). In the
past 10 years, progress has been made in the early identification of septic patients and in …

Ageing is a process that gradually increases the organism's vulnerability to death. It affects
different biological pathways, and the underlying cellular mechanisms are complex. In view …

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. 1 These dysregulated host responses underpin the clinical …

Sepsis is a heterogeneous disease with variable clinical course and several clinical
phenotypes. As it is associated with an increased risk of death, patients with this condition …

Background Interleukin-1 receptor associated kinase 3 (IRAK3) is a critical modulator of
inflammation and is associated with endotoxin tolerance and sepsis. Although IRAK3 is …

Sepsis is a life-threatening organ dysfunction, which demands notable attention for its
treatment, especially in view of the involvement of immunodepressed patients, as the case of …

Older age has long been associated with altered inflammation and hemostasis regulation.
Emerging evidence suggests that age-related differences in inflammation and hemostasis …

Systemic inflammatory disorders (SIDs) comprise a broad range of diseases characterized
by dysregulated excessive innate immune responses. Severe forms of SIDs can lead to …

The aim of this study was to explore the association between some SNPs of the TNF, LTA,
IL1B and IL10 genes with cytokine concentrations and clinical course in Colombian septic …