Introduction Colorectal cancer (CRC) is a devastating disease that affects millions of people
worldwide. Recent research has highlighted the crucial role of the guanylate cyclase-C (GC …

The considerable burden of colorectal cancer and the rising trend in young adults
emphasize the necessity of understanding its underlying mechanisms, providing new …

Background Current evidence suggests that the hypoxic tumor microenvironment further
aggravates tumor progression, leading to poor therapeutic outcomes. There is as yet no …

By 2030, it is anticipated that there will be 2.2 million new instances of colorectal cancer
worldwide, along with 1.1 million yearly deaths. Therefore, it is critical to develop novel …

Background Gap junctions, as one of the major ways to maintain social connections
between cells, are now considered as one of the potential regulators of tumor metastasis …

Colorectal cancer (CRC) is one of the world's leading causes of cancer-related deaths; thus,
it is important to detect it as early as possible. Obesity is thought to be linked to a large rise in …

Etoposide is a second-line chemotherapy agent widely used for metastatic colorectal
cancer. However, we discovered that etoposide treatment induced greater motility potential …

Neuroblastoma (NB) is an embryonic malignant tumor that occurs in the sympathetic
nervous system. The treatment results of patients in the high-risk group are poor, and …

Background: Alzheimer's disease (AD) is the most prevalent neurological disorder
worldwide, affecting approximately 24 million individuals. Despite more than a century of …

Abstract The TBC (Tre-2/Bub2/Cdc16, TBC) structural domain is now considered as one of
the factors potentially regulating tumor progression. However, to date, studies on the …