[HTML][HTML] A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

M Fedele, R Piersanti, F Regazzoni, M Salvador… - Computer Methods in …, 2023 - Elsevier
While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …

Chaste: a test-driven approach to software development for biological modelling

J Pitt-Francis, P Pathmanathan, MO Bernabeu… - Computer Physics …, 2009 - Elsevier
Chaste ('Cancer, heart and soft-tissue environment') is a software library and a set of test
suites for computational simulations in the domain of biology. Current functionality has …

[HTML][HTML] Anatomically accurate high resolution modeling of human whole heart electromechanics: a strongly scalable algebraic multigrid solver method for nonlinear …

CM Augustin, A Neic, M Liebmann, AJ Prassl… - Journal of computational …, 2016 - Elsevier
Electromechanical (EM) models of the heart have been used successfully to study
fundamental mechanisms underlying a heart beat in health and disease. However, in all …

Cardiac arrhythmogenesis: roles of ion channels and their functional modification

M Lei, SC Salvage, AP Jackson, CLH Huang - Frontiers in Physiology, 2024 - frontiersin.org
Cardiac arrhythmias cause significant morbidity and mortality and pose a major public
health problem. They arise from disruptions in the normally orderly propagation of cardiac …

An active strain electromechanical model for cardiac tissue

F Nobile, A Quarteroni… - International journal for …, 2012 - Wiley Online Library
We propose a finite element approximation of a system of partial differential equations
describing the coupling between the propagation of electrical potential and large …

Abnormal calcium homeostasis in heart failure with preserved ejection fraction is related to both reduced contractile function and incomplete relaxation: an …

I Adeniran, DH MacIver, JC Hancox… - Frontiers in physiology, 2015 - frontiersin.org
Heart failure with preserved ejection fraction (HFpEF) accounts for about 50% of heart failure
cases. It has features of incomplete relaxation and increased stiffness of the left ventricle …

Image-based personalization of cardiac anatomy for coupled electromechanical modeling

A Crozier, CM Augustin, A Neic, AJ Prassl… - Annals of biomedical …, 2016 - Springer
Computational models of cardiac electromechanics (EM) are increasingly being applied to
clinical problems, with patient-specific models being generated from high fidelity imaging …

A numerical study of scalable cardiac electro-mechanical solvers on HPC architectures

P Colli Franzone, LF Pavarino, S Scacchi - Frontiers in physiology, 2018 - frontiersin.org
We introduce and study some scalable domain decomposition preconditioners for cardiac
electro-mechanical 3D simulations on parallel HPC (High Performance Computing) …

Reduced order modeling for cardiac electrophysiology and mechanics: New methodologies, challenges and perspectives

A Manzoni, D Bonomi, A Quarteroni - Mathematical and numerical …, 2018 - Springer
Reduced-order modeling techniques enable a remarkable speed up in the solution of the
parametrized electromechanical model for heart dynamics. Being able to rapidly …

Towards a computational framework for modeling the impact of aortic coarctations upon left ventricular load

E Karabelas, MAF Gsell, CM Augustin, L Marx… - Frontiers in …, 2018 - frontiersin.org
Computational fluid dynamics (CFD) models of blood flow in the left ventricle (LV) and aorta
are important tools for analyzing the mechanistic links between myocardial deformation and …