Background Over the last three decades, consumption of total and saturated fat has steadily
declined in Western diets as a proportion of calories intake. At the same time, omega (ω)-6 …

Life expectancy is increasing and so is the prevalence of age-related non-communicable
diseases (NCDs). Consequently, older people and patients present with multi-morbidities …

Omega-3 polyunsaturated fatty acids (PUFAs) are considered immunonutrients and are
commonly used in the nutritional therapy of cancer patients due to their ample biological …

Ingestion of omega-3 fatty acids is known to exert favorable health effects on a number of
biological processes such as improved immune profile, enhanced cognition, and optimized …

Significant progress in our understanding of cancer cachexia has occurred in recent years.
Despite these advances, no pharmacologic agent has achieved US Food and Drug …

No studies have examined the relationship between endogenous polyunsaturated fatty
acids (PUFAs) levels and treatment response to PUFAs. We conducted a 12-week, double …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and extremely therapy-resistant
cancer. It is estimated that up to 80% of PDAC patients present with cachexia, a multifactorial …

Dysregulation of fatty acid metabolism and de novo lipogenesis is a key driver of several
cancer types through highly unsaturated fatty acid (HUFA) signaling precursors such as …

Abstract Background Cancer cachexia (CCx) is a multifactorial energy‐wasting syndrome
reducing the efficiency of anti‐cancer therapies, quality of life, and survival of cancer …

Cancer cachexia can be defined as a complex metabolic syndrome characterized by weight
loss, anorexia, and emaciation due to the wasting of adipose tissue and skeletal muscle. In …