This international guideline proposes improving clozapine package inserts worldwide by
using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest …

Violence and aggression are major public health problems. 2. The authors have used
techniques of electrical brain stimulation, anatomical-immunohistochemical techniques, and …

A major goal of research on addiction is to identify the molecular mechanisms of long‐
lasting behavioural alterations induced by drugs of abuse. Cocaine and delta‐9 …

This review addresses two questions. First, why does clozapine apparently occupy low
levels of dopamine D2 receptors in patients, in contrast to all other antipsychotic drugs which …

The molecular and neuronal substrates conferring on clozapine its unique and superior
efficacy in the treatment of schizophrenia remain elusive. The interaction of clozapine with …

In the past, the information about the dose-clinical effectiveness of typical antipsychotics was
not complete and this led to the risk of extrapyramidal adverse effects. This, together with the …

Metabolism represents the most prevalent mechanism for drug clearance. Many drugs are
converted to metabolites that can retain the intrinsic affinity of the parent drug for the …

Rationale Clozapine is a unique antipsychotic, with efficacy against positive symptoms in
treatment-resistant schizophrenic patients, and the ability to improve cognition and treat the …

OBJECTIVE: To compare the pharmacology, pharmacokinetics, and efficacy of the newer
atypical antipsychotics with those of conventional agents and existing atypical agents. DATA …

This review examines the possible receptor basis of the atypical action of those atypical
antipsychotic drugs that elicit low levels of Parkinsonism. Such an examination requires …