During the past 85 years of antibiotic use, we have learned a great deal about how these
'miracle'drugs work. We know the molecular structures and interactions of these drugs and …

Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

The spread of antibiotic resistance is attracting increased attention to combination-based
treatments. Although drug combinations have been studied extensively for their effects on …

Current machine learning techniques enable robust association of biological signals with
measured phenotypes, but these approaches are incapable of identifying causal …

Highlights•Combinations of antibiotics lead to synergistic and antagonistic drug
interactions.•The underlying mechanisms of drug interactions can be elucidated using novel …

Bacteria can withstand killing by bactericidal antibiotics through phenotypic changes
mediated by their preexisting genetic repertoire. These changes can be exhibited transiently …

Antimicrobial peptides (AMPs) are ancient and conserved across the tree of life. Their
efficacy over evolutionary time has been largely attributed to their mechanisms of killing. Yet …

In bacteremia the majority of bacterial species are killed by oxidation on the surface of
erythrocytes and digested by local phagocytes in the liver and the spleen. Sepsis-causing …

Honey is an organic natural substance that is produced from the nectar of flowers by Apis
mellifera and is a sweet, flavorful liquid. It is one of the most popular natural sweet …

Adiantum philippense (A. philippense), an ethnomedicinally important fern, has become an
interesting herb in the search for novel bioactive metabolites, which can also be used as …