Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …

Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

Zinc (Zn) is an essential trace mineral that regulates the expression and activation of
biological molecules such as transcription factors, enzymes, adapters, channels, and growth …

Around 3000 proteins are thought to bind zinc in vivo, which corresponds to~ 10% of the
human proteome. Zinc plays a pivotal role as a structural, catalytic, and signaling component …

Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of
many cellular proteins. Cellular zinc homeostasis involves the opposing action of two …

Two families of zinc (Zn2+) transporters are involved in zinc homeostasis in the body, SLC30
(ZnT, zinc transporter) and SLC39 (ZIP, Zinc (Zn2+)–Iron (Fe2+) Permease). The two zinc …

Manganese is essential for several metabolic pathways but becomes toxic in excessive
amounts. Manganese levels in the body are therefore tightly regulated, but the responsible …

Abstract Zinc transporters, the Zrt-, Irt-like protein (ZIP) family and the Zn transporter (ZnT)
family transporters, are found in all aspects of life. Increasing evidence has clarified the …

Primary aldosteronism (PA) is the most common form of endocrine hypertension and is
characterized by inappropriately elevated aldosterone production via a renin-independent …

Abstract The Cation Diffusion Facilitators (CDFs) form a family of membrane-bound proteins
capable of transporting zinc and other heavy metal ions. Involved in metal …