Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

Pyroptosis refers to the process of gasdermin (GSDM)‐mediated programmed cell death
(PCD). Our understanding of pyroptosis has expanded beyond cells and is known to involve …

Abstract Pediatric Coronavirus Disease 2019 (pCOVID-19) is rarely severe; however, a
minority of children infected with severe acute respiratory syndrome coronavirus 2 (SARS …

The mammalian immune system evolved to tightly regulate the elimination of pathogenic
microbes and neoplastic transformed cells while tolerating our own healthy cells. Here, we …

The sialic acid–binding immunoglobulin-like lectin (Siglec)–sialic acid immune axis is an
evolutionarily conserved immunoregulatory pathway that provides a mechanism for …

Ovarian cancer (OC) is a lethal gynecologic malignancy, with modest responses to CPI.
Engagement of additional immune arms, such as NK cells, may be of value. We focused on …

Natural killer (NK) cells play a pivotal role in cancer immunotherapy due to their innate
ability to detect and kill tumorigenic cells. The decision to kill is determined by the …

Introduction: During cancer progression, tumor cells develop several mechanisms to prevent
killing and to shape the immune system into a tumor-promoting environment. One of such …

Abstract Group B Streptococcus (GBS) is a pervasive perinatal pathogen, yet factors driving
GBS dissemination in utero are poorly defined. Gestational diabetes mellitus (GDM), a …

The inflammasomes are intracellular multimeric protein complexes consisting of an innate
immune sensor, the adapter protein ASC and the inflammatory caspases-1 and/or-11 and …