Positive allosteric modulators of γ-aminobutyric acid-A (GABA A) receptors or GABAkines
have been widely used medicines for over 70 years for anxiety, epilepsy, sleep, and other …

Epilepsy is a group of chronic neurological disorders that have diverse etiologies but are
commonly characterized by spontaneous seizures and behavioral comorbidities. Although …

Increasing evidence suggests that inflammatory responses are involved in the progression
of brain injuries induced by a diverse range of insults, including ischemia, hemorrhage …

The epilepsies are a diverse spectrum of disease states characterized by spontaneous
seizures and associated comorbidities. Neuron-focused perspectives have yielded an array …

Epilepsy is a group of enduring neurological disorder characterized by spontaneous and
recurrent seizures with heterogeneous etiology, clinical expression, severity, and prognosis …

Posttraumatic epilepsy (PTE) is a prevalent complication of brain trauma. Current anti-
epileptic drugs available do not have satisfactory response to PTE. It is of desperate need to …

Epilepsy, one of the most severe neurological diseases, is characterized by abrupt recurrent
seizures. Despite great progress in the development of antiseizure drugs (ASDs) based on …

High mobility group box 1 (HMGB1) is a ubiquitous and highly conserved non-histone DNA-
binding protein with different biological functions according to its subcellular localization. It is …

Epilepsy is a common neurological disease caused by synchronous firing of hyperexcitable
neurons. Currently, patients with epilepsy are typically treated with antiseizure medicines …

Aims Temporal lobe epilepsy (TLE), often associated with cognitive impairment, is one of the
most common types of medically refractory epilepsy. Deep brain stimulation (DBS) shows …