Certain inflammatory disorders are characterized by macrophage activation and
accumulation in tissue; sometimes leading to the formation of granulomas, as in sarcoidosis …

VOL. 107 NO. 2 I FEBRUARY 2021 75 WWW. MDEDGE. COM/DERMATOLOGY systemic
disease can improve their quality of life and help prevent severe systemic complications …

Background: Necrobiosis lipoidica (NL) is a rare granulomatous disorder of unknown
aetiology. Randomized controlled studies are not available due to it being an orphan …

Since so many years people have been trying to heal wounds. Ancient people used so
many herbal products to heal wounds like ghee, honey, leaves of different trees, wine, milk …

Granulomatous skin conditions are poorly understood inflammatory skin diseases consisting
predominantly of macrophages. Granuloma annulare (GA) is the most common …

Objectives: Describe the pathophysiology of necrobiosis lipoidica. Review the presentation
of necrobiosis lipoidica. Summarize the treatment of necrobiosis lipoidica. Outline the …

Background Necrobiosis lipoidica (NL) is a rare, idiopathic, and recalcitrant disease of
collagen degeneration for which treatment options have been poorly studied. Due to its …

Granulomatous dermatoses comprise a wide range of etiologically and clinically distinct skin
diseases that share a common histology characterized by the accumulation of histiocytes …

Discussion The clinical response of this patient's NL to ruxolitinib expands on emerging data
that JAK inhibitors are a promising treatment for granulomatous disorders. In granulomatous …

Granulomatous skin disorders comprise a large group of diseases that are typically
characterized by granuloma formation both in the skin and in many other tissues. Cutaneous …