[HTML][HTML] Neurodegeneration in diabetic retinopathy: does it really matter?

R Simó, AW Stitt, TW Gardner - Diabetologia, 2018 - Springer
The concept of diabetic retinopathy as a microvascular disease has evolved, in that it is now
considered a more complex diabetic complication in which neurodegeneration plays a …

Emerging roles of exosomal miRNAs in diabetes mellitus

X He, G Kuang, Y Wu, C Ou - Clinical and translational …, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles 40–160 nm in diameter that are secreted by
almost all cell types. Exosomes can carry diverse cargo including RNA, DNA, lipids …

Development and cell biology of the blood-brain barrier

UH Langen, S Ayloo, C Gu - Annual review of cell and …, 2019 - annualreviews.org
The vertebrate vasculature displays high organotypic specialization, with the structure and
function of blood vessels catering to the specific needs of each tissue. A unique feature of …

The progress in understanding and treatment of diabetic retinopathy

AW Stitt, TM Curtis, M Chen, RJ Medina… - Progress in retinal and …, 2016 - Elsevier
Diabetic retinopathy is the most frequently occurring complication of diabetes mellitus and
remains a leading cause of vision loss globally. Its aetiology and pathology have been …

Photoreceptor cells and RPE contribute to the development of diabetic retinopathy

D Tonade, TS Kern - Progress in retinal and eye research, 2021 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as
vascular disease, but work in the past years has shown abnormalities also in the neural …

lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA

B Yan, J Yao, JY Liu, XM Li, XQ Wang, YJ Li… - Circulation …, 2015 - Am Heart Assoc
Rationale: Pathological angiogenesis is a critical component of diseases, such as ocular
disorders, cancers, and atherosclerosis. It is usually caused by the abnormal activity of …

[HTML][HTML] Quantifying microvascular abnormalities with increasing severity of diabetic retinopathy using optical coherence tomography angiography

PL Nesper, PK Roberts, AC Onishi… - … & visual science, 2017 - jov.arvojournals.org
Purpose: We quantified retinal and choriocapillaris microvascular changes in healthy control
eyes and different stages of diabetic retinopathy (DR) using optical coherence tomography …

[HTML][HTML] Diabetic retinopathy: hyperglycaemia, oxidative stress and beyond

HP Hammes - Diabetologia, 2018 - Springer
Diabetic retinopathy remains a relevant clinical problem. In parallel with diagnostic and
therapeutic improvements, the role of glycaemia and reactive metabolites causing cell stress …

[HTML][HTML] Vascular complications of diabetes: mechanisms of injury and protective factors

C Rask-Madsen, GL King - Cell metabolism, 2013 - cell.com
In patients with diabetes, atherosclerosis is the main reason for impaired life expectancy,
and diabetic nephropathy and retinopathy are the largest contributors to end-stage renal …

Methods and algorithms for optical coherence tomography-based angiography: a review and comparison

A Zhang, Q Zhang, CL Chen… - Journal of biomedical …, 2015 - spiedigitallibrary.org
Optical coherence tomography (OCT)-based angiography is increasingly becoming a
clinically useful and important imaging technique due to its ability to provide volumetric …