Immunocompromised individuals are at high risk of developing severe fungal infections with
high mortality rates, while fungal pathogens pose little risk to most healthy people. Poor …

Cryptococcus is an invasive fungus that seriously endangers human life and health, with a
complex and well-established immune-escaping mechanism that interferes with the function …

Macrophages play a key role in disseminated cryptococcosis, a deadly fungal disease
caused by Cryptococcus neoformans. This opportunistic infection can arise following the …

A multifunctional glycoprotein, osteopontin (OPN), can modulate the function of
macrophages, resulting in either protective or deleterious effects in various inflammatory …

Cryptococcus neoformans is an opportunistic fungal pathogen that causes over 180,000
annual deaths in HIV/AIDS patients. Innate phagocytes in the lungs, such as dendritic cells …

Macrophages are tissue resident innate phagocytic cells that take on contrasting
phenotypes, or polarization states, in response to the changing combination of microbial and …

With over 220,000 cases and 180,000 deaths annually, Cryptococcus neoformans is the
most common cause of fungal meningitis and a leading cause of death in HIV/AIDS patients …

Cryptococcus neoformans is a facultative intracellular pathogen that can replicate and
disseminate in mammalian macrophages. In this study, we analyzed fungal proteins …

Macrophages serve as a first line of defense against microbial pathogens. Exposure to
interferon-γ (IFNγ) increases interferon-stimulated gene (ISG) expression in these cells …

Cryptococcus gattii (Cg) is a facultative intracellular pathogen that can replicate and
disseminate in mammalian macrophages, causing life-threatening cryptococcosis in both …