Abstract Changes in the neuromuscular system affecting the ageing motor unit manifest
structurally as a reduction in motor unit number secondary to motor neuron loss; fibre type …

Identification of cost-effective interventions to maintain muscle mass, muscle strength, and
physical performance during muscle wasting and aging is an important public health …

Mitochondria regulate cellular bioenergetics and apoptosis and have been implicated in
aging. However, it remains unclear whether age‐related loss of muscle mass, known as …

Age-related loss of skeletal muscle mass and function is a major contributor to morbidity and
has a profound effect on the quality of life of older people. The potential role of age …

Background Oxidative stress and damage are associated with a number of ageing
phenotypes, including age‐related loss of muscle mass and reduced contractile function …

Molecular targets to reduce muscle weakness and atrophy due to oxidative stress have
been elusive. Here we show that activation of Sarcoplasmic Reticulum (SR) Ca 2+ ATPase …

The mammalian neuromuscular junction (NMJ) comprises a presynaptic terminal, a
postsynaptic receptor region on the muscle fiber (endplate), and the perisynaptic (terminal) …

Skeletal muscle is a major site of metabolic activity and is the most abundant tissue in the
human body. Age‐related muscle atrophy (sarcopenia) and weakness, characterized by …

Denervation and mitochondrial impairment are implicated in age-related skeletal muscle
atrophy and may play a role in physical frailty. We recently showed that denervation …

Aim To examine whether hypertensive individuals exhibit altered muscle mitochondrial
turnover and redox homeostasis compared with healthy normotensive counterparts, and …