Reactive oxygen species and cancer paradox: to promote or to suppress?

S Galadari, A Rahman, S Pallichankandy… - Free Radical Biology …, 2017 - Elsevier
Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

Environmental chemicals, breast cancer progression and drug resistance

M Koual, C Tomkiewicz, G Cano-Sancho… - Environmental …, 2020 - Springer
Breast cancer (BC) is one of the most common causes of cancer in the world and the second
leading cause of cancer deaths among women. Mortality is associated mainly with the …

Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy

M López-Lázaro - Cancer letters, 2007 - Elsevier
Accumulating evidence suggests that hydrogen peroxide (H2O2) plays an important role in
cancer development. Experimental data have shown that cancer cells produce high …

Redox signaling in angiogenesis: role of NADPH oxidase

M Ushio-Fukai - Cardiovascular research, 2006 - academic.oup.com
Angiogenesis, a process of new blood vessel formation, is a key process involved in normal
development and wound repair as well as in the various pathophysiologies such as …

Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity

M Ding, R Feng, SY Wang, L Bowman, Y Lu… - Journal of Biological …, 2006 - ASBMB
Epidemiological data suggest that consumption of fruits and vegetables has been
associated with a lower incidence of cancer. Cyanidin-3-glucoside (C3G), a compound …

Oxygen free radicals and redox biology of organelles

L Moldovan, NI Moldovan - Histochemistry and cell biology, 2004 - Springer
The presence and supposed roles of reactive oxygen species (ROS) were reported in
literature in a myriad of instances. However, the breadth and depth of their involvement in …

[HTML][HTML] Anti-oxidant potential of plants and probiotic spp. in alleviating oxidative stress induced by H2O2

H Kumar, R Dhalaria, S Guleria, R Cimler… - Biomedicine & …, 2023 - Elsevier
Cells produce reactive oxygen species (ROS) as a metabolic by-product. ROS molecules
trigger oxidative stress as a feedback response that significantly initiates biological …

Hydrogen peroxide alters membrane and cytoskeleton properties and increases intercellular connections in astrocytes

D Zhu, KS Tan, X Zhang, AY Sun… - Journal of cell …, 2005 - journals.biologists.com
Excess hydrogen peroxide (H2O2) is produced in the pathogenesis of brain injuries and
neurodegenerative diseases. H2O2 may damage cells through direct oxidation of lipids …

Pro-oxidant natural products as anticancer agents

C Martin-Cordero, A Jose Leon-Gonzalez… - Current drug …, 2012 - ingentaconnect.com
Cancer cells produce high levels of reactive oxygen species (ROS) that lead to a state of
increased basal oxidative stress. Since this state of oxidative stress makes cancer cells …

Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 …

V Thakur, MT Pritchard, MR McMullen… - Journal of leukocyte …, 2006 - academic.oup.com
Reactive oxygen species (ROS) contribute to the development of chronic ethanol-induced
liver injury. Although ROS modulate the activity of many signal transduction pathways, the …